Molecular Cell
Volume 45, Issue 3, 10 February 2012, Pages 314-329
ArticlehnRNP A1 Proofreads 3′ Splice Site Recognition by U2AF
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Graphical Abstract
Highlights
► hnRNP A1 displaces U2AF from uridine-rich RNAs not followed by a 3′ splice site AG ► A 3′ splice site AG allows formation of a ternary complex with hnRNP A1 and U2AF ► AG proofreading requires U2AF35 and the glycine-rich domain of hnRNP A1 ► hnRNP A1-mediated proofreading influences U2 snRNP recruitment
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Present address: NMR Spectroscopy Research Group, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
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