TRP channels in thermosensation

https://doi.org/10.1016/j.conb.2022.102591Get rights and content
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Abstract

The ability to sense external temperature is assumed by somatosensory neurons, in which temperature information is converted to neural activity by afferent input to the central nervous system. Somatosensory neurons consist of various populations with specialized gene expression, including thermosensitive transient receptor potential ion channels (thermo-TRPs). Thermo-TRPs are responsible for thermal transduction at the peripheral ends of somatosensory neurons and over a wide range of temperatures. In this review, we focus on several thermo-TRPs expressed in sensory neurons: TRPV1, TRPV4, TRPM2, TRPM3, TRPM8, TRPC5, and TRPA1. TRPV3, TRPV4, and TRPC5 expressed in non-neuronal cells that are also involved in somatosensation are also discussed, whereas TRPM2 and TRPM8 are involved in thermosensation in the brain.

Abbreviations

TRP
transient receptor potential
TRPV
transient receptor potential Vanilloid
TRPM
transient receptor potential Melastatin
TRPA
transient receptor potential ankyrin
TRPC
transient receptor potential canonical
CNS
central nervous system
TG
trigeminal ganglion
DRG
dorsal root ganglion
POA
preoptic area
thermo-TRPs
thermosensitive TRP channels
CHO
chinese hamster ovary
HEK
human embryonic kidney

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