Cell Reports
Volume 24, Issue 2, 10 July 2018, Pages 278-283
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Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits

https://doi.org/10.1016/j.celrep.2018.06.053Get rights and content
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Highlights

  • Conditioned taste aversion (CTA) leads to re-mapping in the gustatory cortex (GC)

  • Neuronal responses to conditioned tastants resemble those to innately aversive tastants

  • Conditioned tastants evoke larger responses compared to innately aversive tastants

Summary

Avoidance of potentially toxic food by means of conditioned taste aversion is critical for survival of many animals. However, the underlying neuronal mechanisms are poorly understood. Here, using two-photon calcium imaging of defined gustatory cortex neurons in vivo, we show that conditioned taste aversion dynamically shifts neuronal population coding by stimulus-specific recruitment of neurons that project to the basolateral amygdala.

Keywords

CTA
gustatory cortex
BLA
calcium imaging
associative learning
conditioning

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