Cell
Volume 151, Issue 7, 21 December 2012, Pages 1581-1594
ArticleMultiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95
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Graphical Abstract
Highlights
► The transcription factor MEF2 induces Pcdh10 that is required for synapse elimination ► MEF2 stimulates ubiquitination of PSD-95 by the ubiquitin E3 ligase Mdm2 ► Pcdh10 chaperones ubiquitinated PSD-95 to proteasome ► Elevated EF1α in Fmr1 KO neuron blocks Mdm2 and MEF2-mediated synapse elimination
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These authors contributed equally to this work
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Present address: Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
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