Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Archival ReportAssociation Between Duration of Untreated Psychosis and Frontostriatal Connectivity During Maintenance of Visuospatial Working Memory
Section snippets
Participants
Thirty-seven patients with FEP were included in this study and were recruited from clinical services at the University of Pittsburgh Medical Center. Patients ranged from 12 to 40 years of age and were diagnosed with a first episode of a psychotic disorder, including schizophrenia (n = 19), schizophreniform disorder (n = 6), schizoaffective disorder (n = 5), or psychotic disorder, not otherwise specified (n = 7). Diagnoses were determined based on consensus discussions of a Structured Clinical
Participant Characteristics and WM Performance
Demographic and clinical information for all participants is shown in Table 1. The median DUP of our cohort of participants was 365 days (Supplemental Figure S2). The mean dose of antipsychotic treatment at time of scanning in chlorpromazine equivalents was 148.62 mg. Average WM accuracy during the low and high loads of the task in the FEP group was 89% and 82%, and reaction times were reaction times were 1036 ms and 1046 ms, respectively. Consistent with previous work that included a subset of
Discussion
We examined whether DUP is related to visuospatial WM activation within the DLPFC and functional connectivity between the dorsal striatum and the DLPFC during WM maintenance. No significant association was found between DUP and WM performance measures. Similarly, no significant relationships between DUP and WM activation were noted for either low or high WM loads across all task conditions. As hypothesized, DUP was associated with differential engagement of frontostriatal circuitry during
Acknowledgments and Disclosures
This work was supported by a National Alliance for Research on Schizophrenia and Depression Young Investigator Award from the Brain and Behavior Research Foundation (to DKS), National Institute of Mental Health Grant Nos. K23MH110661 (to DKS), K01MH112774 (to MJ), and P50MH103204 to the Conte Center for Translational Mental Health Research (principal investigator, David A. Lewis, M.D.), and National Center for Advancing Translational Sciences Grant No. UL1TR001857 to the Clinical and
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Load-dependent functional connectivity deficits during visual working memory in first-episode psychosis
2022, Journal of Psychiatric ResearchCitation Excerpt :Recent studies in FESz have found similar load-dependent disruptions rather than across-the-board deficits (Manivannan et al., 2019; Nielsen et al., 2017; Schmidt et al., 2013) suggesting a progressive nature of dysconnectivity in schizophrenia,. Further emphasizing the importance of treatment during early disease course, some of these studies observed an amelioration of deficits in network connectivity with antipsychotic treatment and shorter durations of untreated psychosis (Manivannan et al., 2019; Nielsen et al., 2017). Although no effect of medication was observed in the present study, this may be related to the relatively short window between first clinical contact and testing.
Association between duration of untreated psychosis and executive function in early-onset psychosis
2021, Journal of Affective Disorders ReportsCitation Excerpt :This study showed significant association (p-value 0.003) between working memory and DUP, which was consistent with (Lappin et al., 2007) study that found association between longer DUP and impaired verbal working memory at time of first presentation in FEP. The mechanism that underlies the influence of DUP towards working memory may be explained by recent experimental study, in which FEP patients with longer DUP showed less functional frontostriatal connectivity while maintaining the increasing working memory load (Ashwinee Manivannan et al., 2019). However, a meta-analysis by (Bora et al., 2018) reported no significant association between DUP and working memory in FEP patients.
Duration of Untreated Psychosis Correlates With Brain Connectivity and Morphology in Medication-Naïve Patients With First-Episode Psychosis
2020, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingCitation Excerpt :Similar to us, they found that corticostriatal connectivity mediated the relationship between DUP and treatment response. More recently, Manivannan et al. (21) reported correlations between task-based functional MRI using a visuospatial working memory task with DUP in patients with FEP (22 medication naïve and 12 with prior APD exposure). We observed negative correlations between surface area of SN and CEN, and positive correlations between cortical thickness of DMN and SN with DUP.
The Duration of Untreated Psychosis and Frontostriatal Connectivity: Toward Understanding the Impact of Untreated Psychosis on Brain Function
2019, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging