Archival ReportIncubation of Cocaine Craving After Intermittent-Access Self-administration: Sex Differences and Estrous Cycle
Section snippets
Methods and Materials
For information on subjects, see the Supplement.
Cocaine Self-administration
During the acquisition phase in sessions 1 to 4 (2 hours/day continuous access) there were no sex differences in the number of infusions, the frequency of infusions (infusions/min), and active and inactive lever presses (Figure 1B–E). Results showed that escalation of cocaine intake of days was observed under both access conditions, that total daily drug intake and the number of active lever presses were higher in the continuous-access condition, that infusion rate per minute and the number of
Discussion
We examined the effect of intermittent cocaine self-administration on incubation of cocaine craving in male and female rats. There are four main findings in our study. First, incubation of cocaine craving during abstinence was observed after intermittent-access drug self-administration, extending previous reports using the classical continuous-access training procedure 9, 13, 63. Second, in both male and female rats and independent of the abstinence day, intermittent-access cocaine
Acknowledgments and Disclosures
The research was supported by the Intramural Research Program of National Institute on Drug Abuse (to SI and YS) and a fellowship from the National Institute on Drug Abuse–French Institute of Health and Medical Research program (to CN).
CN, TIR, AP, SM, AH, and Z-BY carried out the experiments; CN and TIR performed data analysis. CN, MMC, AH, YS, and SI designed the study. CN, YS, and SI wrote the manuscript. All authors critically reviewed the content and approved the final version before
References (87)
- et al.
Incubation of cocaine craving after withdrawal: A review of preclinical data
Neuropharmacology
(2004) - et al.
Neurobiology of the incubation of drug craving
Trends Neurosci
(2011) - et al.
Animal models of drug relapse and craving: From drug priming-induced reinstatement to incubation of craving after voluntary abstinence
Prog Brain Res
(2016) - et al.
Synaptic plasticity model of therapeutic sleep deprivation in major depression
Sleep Med Rev
(2016) - et al.
How fast and how often: The pharmacokinetics of drug use are decisive in addiction
Neurosci Biobehav Rev
(2015) - et al.
Intermittent intake of rapid cocaine injections promotes robust psychomotor sensitization, increased incentive motivation for the drug and mGlu2/3 receptor dysregulation
Neuropharmacology
(2017) - et al.
Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration
Neuropharmacology
(2014) - et al.
Conflation of cocaine seeking and cocaine taking responses in IV self-administration experiments in rats: Methodological and interpretational considerations
Neurosci Biobehav Rev
(2013) - et al.
Comparing levels of cocaine cue reactivity in male and female outpatients
Drug Alcohol Depend
(1999) - et al.
The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals
Adv Pharmacol
(2014)