Archival ReportBrain Corticostriatal Systems and the Major Clinical Symptom Dimensions of Obsessive-Compulsive Disorder
Section snippets
Participants
Seventy-four adult outpatients were recruited from the Obsessive-Compulsive Disorders Unit of the University Hospital of Bellvitge, Barcelona, Spain. Patients were selected from a slightly larger cohort after having satisfied DSM-IV diagnostic criteria for OCD (for at least 1 year before the study), in the absence of relevant medical, neurologic, and other major psychiatric illness, as well as imaging data quality control checks (see below). Nineteen of these patients (26%) were included in our
Initial Group Analyses
Robust functional connectivity maps were obtained in each group that reproduced the expected connectional anatomy of the ventral and dorsal caudate regions 19, 20, 21, 27, 28, 29. Figure 1 highlights the significant within-group effects for each region, as well as the relative overlap seen between control subjects and OCD patients. Table S1 in Supplement 1 lists all significant regional clusters for these within-group effects.
Significant between-group differences in functional connectivity were
Discussion
The notion that OCD should be understood as a spectrum of multiple potentially overlapping clinical syndromes has gained traction over the past decade with the introduction of the multidimensional model 8, 9 and the development of specific instruments to assess its proposed major symptom dimensions (23). Despite heuristic appeal, it has nevertheless remained unclear whether these dimensions may actually reflect distinct, or partially distinct, pathophysiological mechanisms. Our current results
References (62)
The primate basal ganglia: Parallel and integrative networks
J Chem Neuroanat
(2003)- et al.
Pathophysiology of obsessive-compulsive disorder: A necessary link between phenomenology, neuropsychology, imagery and physiology
Prog Neurobiol
(2004) - et al.
Toward a neurobiology of obsessive-compulsive disorder
Neuron
(2000) - et al.
Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited
Neurosci Biobehav Rev
(2008) - et al.
Brain structure and symptom dimension relationships in obsessive-compulsive disorder: A voxel-based morphometry study
J Affect Disord
(2008) - et al.
Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD
Biol Psychiatry
(2007) - et al.
Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
Biol Psychiatry
(2007) - et al.
Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder
Eur Psychiatry
(2011) - et al.
Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: A resting-state fMRI study
J Affect Disord
(2012) - et al.
Aberrant striatal functional connectivity in children with autism
Biol Psychiatry
(2011)