Archival ReportEvidence of a Dissociation Pattern in Resting-State Default Mode Network Connectivity in First-Episode, Treatment-Naive Major Depression Patients
Section snippets
Participants
Patients with MDD were recruited from the outpatient department at Second Xiangya Hospital of Central South University in Changsha, Hunan, China. Closely matched healthy subjects were recruited through advertisements from several colleges in Changsha. All participants were aware of the purpose of the study before participating in the study and signed an informed consent form approved by the Ethics Committee of the Second Xiangya Hospital. Finally, 37 patients with MDD (21 female patients) and
Participants
The demographic and clinical characteristics of the two groups of participants are shown in Table 1. The groups did not differ significantly in terms of age or gender. Compared with healthy control subjects, MDD patients showed higher levels of CES-D (t = 11.12, p < .001), CERQ-rumination (t = 6.24, p < .001), and AMT-OGM (t = 11.77, p < .001).
Additional correlation analyses showed that there was significantly positive correlation between the CES-D and AMT-OGM (r = .36, p < .01) in the present
Discussion
Using ICA methodology, our study demonstrated altered resting-state DMNs in first-episode, treatment-naive young adults with MDD. Compared with healthy control subjects, MDD patients showed greater functional connectivity in the MPFC/vACC areas, as well as decreased functional connectivity in the PCC/precuneus and bilateral AG areas. The relatively large effect size (Cohen's d) of the findings on those clusters lends a quantitative measure to the qualitative impression. Furthermore, the MDD
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Cited by (0)
Authors XZ and XW contributed equally to this work.