ReviewA Review of Functional Brain Imaging Correlates of Successful Cognitive Aging
Section snippets
Methods and Materials
To retrieve studies for this review, we surveyed MEDLINE citations (January 1989–December 2009, human studies, in English) with the National Library of Medicine PubMed online search engine with the following search string: (“functional MRI” OR “fMRI” OR “functional magnetic resonance imaging” OR “PET” OR “positron emission tomography” OR “cerebral blood flow”) AND (brain OR cognition OR cognitive OR cerebral) AND (age[Title] OR aging[Title] OR aging[Title] OR old[Title] OR elderly[Title]) NOT
Characteristics of Reviewed Studies
Study characteristics and results for the 80 reviewed articles are presented chronologically in Table S1 in Supplement 1. There were two reports from the same longitudinal study (64, 80); two studies examined cognitive change longitudinally and brain response only once (54, 78); all other investigations were cross sectional. Among cross sectional studies, six (27, 41, 45, 47, 72, 73) included only older participants, one examined a large cohort ranging in age from 20 to 87 (21), and the rest (n
Discussion
In our review of studies addressing how brain function relates to cognitive performance among older individuals, we found frequent support for the notion that increased brain responsiveness is associated with better cognitive performance. Positive correlations between frontal cortex brain response and performance were more frequently reported than negative correlations, and positive associations were more often observed in frontal cortex than in other regions. Positive correlations also
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Power shift and connectivity changes in healthy aging during resting-state EEG
2022, NeuroImageCitation Excerpt :Several studies have provided support to the HAROLD and PASA models (Schneider-Garces et al., 2010; Cabeza and Dennis, 2012; Ansado et al., 2012; Li et al., 2015; Tagliabue et al., 2022). Nonetheless, a thorough understanding of the mechanisms underlying higher frontal activations in older adults is lacking (Eyler et al., 2011; Morcom and Johnson, 2015). In particular, it is not clear whether the increase in activity in anterior areas is due to increased activity within those areas or to a higher engagement of those areas in a network, i.e. an increased connectivity between regions.
MRI characterization of rat brain aging at structural and functional level: Clues for translational applications
2021, Experimental Gerontology