Archival ReportHuman microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways
Section snippets
Spanish Sample
Between 2001 and 2006, 203 consecutive adult Spanish outpatients (mean age 35.89 ± 9.74 years, 151 women; mean age of PD onset 29.44 ± 9.44 years) with PD recruited from the psychiatry unit in Hospital del Mar (Barcelona) were studied. The diagnosis of PD was independently assigned by two senior psychiatrists with the Structured Clinical Interview for DSM-IV Disorders—Clinician Version. Concurrent agoraphobia was present in 135 (66.5%) patients. Exclusion criteria were age under 18, organic
Association of miRNA Regions with PD in the Spanish Population
Case-control studies in 203 patients with PD and 341 control subjects from Spain were performed for the 712 SNPs in the miRNA SNP panel that passed quality control criteria. As shown in Table 1, the strongest association was found for rs11763020, an SNP tagging miR-339, which remained significant after correction for the 712 SNPs tested (unadjusted p = .00008) but not after correction for the different genetic models analyzed. Besides miR-339, two SNPs tagging miR-22 were also found to
Discussion
Increasing evidence indicates that genetic variation in regulatory regions could be a major contributor to phenotypic diversity in human populations (37, 38). This might be particularly true in the case of psychiatric disorders; changes in regulatory elements leading to small variations in the dosage of proteins involved in neuronal pathways might disrupt the fine-tuned equilibrium of complex brain functions and contribute to the development of psychiatric disorders. Recently, miRNAs have
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Authors MM-G and YE-P contributed equally to this work.