Archival ReportHyperactive Error Responses and Altered Connectivity in Ventromedial and Frontoinsular Cortices in Obsessive-Compulsive Disorder
Section snippets
Subjects
Data were analyzed from 39 OCD patients and 38 control subjects. Twenty OCD patients were unmedicated (uOCD) and 19 were medicated (mOCD), primarily with serotonin reuptake inhibitors (SRIs). All met DSM-IV criteria for primary OCD (see Methods and Materials in Supplement 1 for exclusion criteria). The control group included 20 unmedicated healthy control (uHC) subjects without psychiatric diagnoses and 18 medicated patient control subjects (mPC) who were on SRIs for major depression (in
Behavioral
Error rates and reaction times are shown in Results and Table S3 in Supplement 1. Groups did not differ in number of errors or perception of error frequency (p > .1 for all effects), but OCD patients were more flustered by mistakes [F(1,73) = 5.8, p = .02] and marginally more frustrated with their performance [F(1,73) = 3.3, p = .075].
Errors Versus Corrects
Control and OCD groups exhibited similar patterns of activations for errors > corrects, averaged across incentive value, within the FST area (Figure 2A, Table 1;
Discussion
Using a task that varied the monetary consequences of mistakes to examine how motivational factors modulate error-related neural processing, we have shown that OCD patients exhibit greater activity in VMPFC due to a failure to deactivate this DMN region to the same extent as control subjects, both across all error types and specifically for errors associated with loss. Patients also showed more activation in aI/fO and altered functional connectivity between aI/fO and VMPFC, independent of
References (66)
- et al.
Neuroimaging studies of obsessive-compulsive disorder in adults and children
Clin Psychol Rev
(2006) A cybernetic model of obsessive-compulsive psychopathology
Compr Psychiatry
(1987)- et al.
A meta-analysis of functional neuroimaging in obsessive-compulsive disorder
Psychiatry Res
(2004) - et al.
Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited
Neurosci Biobehav Rev
(2008) - et al.
Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: An event-related fMRI study
Neuroimage
(2005) - et al.
Error-related brain activity in obsessive-compulsive undergraduates
Psychiatry Res
(2002) - et al.
Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder
Biol Psychiatry
(2005) - et al.
Overactive performance monitoring in obsessive-compulsive disorder: ERP evidence from correct and erroneous reactions
Neuropsychologia
(2008) - et al.
A functional magnetic resonance imaging study of inhibitory control in obsessive-compulsive disorder
Psychiatry Res
(2009) - et al.
Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder
Biol Psychiatry
(2007)
A core system for the implementation of task sets
Neuron
An insular view of anxiety
Biol Psychiatry
Functional neuroanatomy of autonomic regulation
Neuroimage
The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology
Prog Neurobiol
An automatic valuation system in the human brain: Evidence from functional neuroimaging
Neuron
Performance monitoring and error significance in patients with obsessive-compulsive disorder
Biol Psychol
A method for using blocked and event-related fMRI data to study “resting state” functional connectivity
Neuroimage
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Comput Biomed Res
Intolerance of uncertainty correlates with insula activation during affective ambiguity
Neurosci Lett
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Neuroimage
Neural correlates of individual ratings of emotional salience: A trial-related fMRI study
Neuroimage
Functional-anatomic fractionation of the brain's default network
Neuron
Large-scale brain networks in cognition: Emerging methods and principles
Trends Cogn Sci
Default-mode brain dysfunction in mental disorders: A systematic review
Neurosci Biobehav Rev
Neural systems for error monitoring: Recent findings and theoretical perspectives
Neuroscientist
Provocation of obsessive-compulsive symptoms: A quantitative voxel-based meta-analysis of functional neuroimaging studies
J Psychiatry Neurosci
Overactive action monitoring in obsessive-compulsive disorder: Evidence from functional magnetic resonance imaging
Psychol Sci
Chronic medication does not affect hyperactive error responses in obsessive-compulsive disorder
Psychophysiology
Action-monitoring dysfunction in obsessive-compulsive disorder
Psychol Sci
Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control
Br J Psychiatry
Probing striatal function in obsessive-compulsive disorder: A PET study of implicit sequence learning
J Neuropsychiatry Clin Neurosci
A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
Proc Natl Acad Sci U S A
Dissociable intrinsic connectivity networks for salience processing and executive control
J Neurosci
Cited by (107)
Cognitive Neuroscience of Obsessive-Compulsive Disorder
2023, Psychiatric Clinics of North AmericaCitation Excerpt :In a recent meta-analysis of functional magnetic resonance imaging (fMRI) studies of error processing in adults with OCD, patients showed significantly greater activation of dorsal MFC regions (dACC, SMA, and pre-SMA), right aI/fO, and anterior lateral prefrontal cortex in response to errors compared with HCs.14 Although not found in the meta-analytic results, two earlier studies found greater activation (or reduced deactivation) of the ventromedial prefrontal cortex (vmPFC) in response to errors in OCD children15 and adults16 compared with control subjects. The vmPFC is a key area of the default mode network (DMN) that typically deactivates during externally focused cognitive tasks,17,18 including the detection of errors,16 but activates more (or deactivates less) during tasks of internally focused cognition such as event imagination, episodic memory, and self-processing.17,19
Abnormal spontaneous neural activity as a potential predictor of early treatment response in patients with obsessive–compulsive disorder
2022, Journal of Affective DisordersError-Related Brain Activity in Patients With Obsessive-Compulsive Disorder and Unaffected First-Degree Relatives: Evidence for Protective Patterns
2022, Biological Psychiatry Global Open ScienceError-related activity of the sensorimotor network contributes to the prediction of response to cognitive-behavioral therapy in obsessive–compulsive disorder
2022, NeuroImage: ClinicalCitation Excerpt :Although the flanker task successfully activated the cingulo-opercular salience network in OCD patients and healthy control participants, the group differences for the postcentral gyrus and precuneus are located outside these regions. In line with this, some previous studies have shown that error monitoring alterations in OCD might not only be characterized by an increased activity of the cingulo-opercular network, but also by broader activation within this network and the recruitment of additional brain regions (Fitzgerald et al., 2010; Grutzmann et al., 2016; Grützmann et al., 2021; Stern et al., 2011). In a combined EEG-FMRI study we observed that the increased ERN amplitude in OCD was related to an altered generator configuration: while the MCC contributed to ERN amplitude in both groups, an additional generator within the SMA was selectively present in the patient group (Grutzmann et al., 2016).