Archival ReportThe Role of the Corpus Callosum in Transcranial Magnetic Stimulation Induced Interhemispheric Signal Propagation
Section snippets
Participants
Thirty right-handed healthy subjects (mean age = 34.0 ± 7.9, range = 20–48 years; 18 males, 12 females) completed TMS-EEG procedures, of whom 19 completed DTI (mean age = 35.7 ± 6.5 years, range = 23–47 years; 14 males, five females). All subjects were recruited via advertisements or self-referral, and psychopathology was ruled out through the Personality Assessment Screener (Psychological Assessment Resources, Lutz, Florida). Exclusion criteria included a self-reported medical illness or a
TMS-EEG
Active suprathreshold stimulation of the left motor cortex resulted in significant activation of the right motor cortex compared with sham (active: 297.1 ± 183.3 μv.msec, sham: 106.1 ± 51.7 μv.msec; t = 5.7, df = 25, p < .001; Figure 2A). In the active condition, activation of the right motor cortex was significantly lower compared with the activity in left motor cortex (right: 291.31 ± 175.54 μv.msec, left: 797.1 ± 536.4 μv.msec; t = 6.0, df = 29, p < .001; Figure 2B). The mean TMS-induced
Discussion
This study represents the first attempt to investigate directly the relationship between ISP of TMS-induced cortical evoked potentials and microstructural integrity of the corpus callosum. Our findings provide in vivo support for the theory that the corpus callosum may serve to limit “excessive crosstalk” between hemispheres when cortical regions are asymmetrically activated. First, there was a significant inverse correlation between TMS-induced ISP in the motor cortex and FA in callosal motor
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Authors ANV and FF contributed equally to this article.