Original articleParvalbumin Neurons in the Entorhinal Cortex of Subjects Diagnosed With Bipolar Disorder or Schizophrenia
Section snippets
Human Subjects
Postmortem tissue blocks containing the whole ECx from 10 SZ, 10 BD, and 16 normal control donors (one hemisphere/subject) were obtained from the Harvard Brain Tissue Resource Center, Belmont, Massachusetts (Table 1). Diagnoses were made by retrospective review of medical records and an extensive questionnaire about social and medical history provided by family members of the donor. In combination, these records provided information on each subject starting from the onset of the disease or
ECx Volume
The volume (mean ± SD) of the ECx was not found to be altered in BD (315.59 ± 82.7 mm3) or SZ (318.35 ± 148.9 mm3), in comparison with normal control subjects (304.04 ± 134.4 mm3) (Figure 3). The values measured in our study are consistent with those reported by other research groups (Bussiere et al 2002, Krimer et al 1997). Brain weight was found to be a significant covariate (p = .01) and was included in the baseline regression model. None of the other covariates were found to have
Discussion
These results indicate that the Tn and Nd of PVB-IR neurons are decreased in the ECx of BD patients. To our knowledge, this is the first evidence for a disruption of inhibitory intrinsic PVB-IR neurons in the ECx of BD subjects. No significant changes were detected in SZ subjects, with the exception of a cell size decrease restricted to the ECx-I.
References (131)
- et al.
Abnormal cholecystokinin mRNA levels in entorhinal cortex of schizophrenics
J Psychiatr Res
(1997) - et al.
Sensory gating deficits in psychiatric inpatients: relation to catecholamine metabolites in different diagnostic groups
Biol Psychiatry
(1990) - et al.
Selective deficits in prefrontal cortical GABAergic neurons in schizophrenia defined by the presence of calcium-binding proteins
Biol Psychiatry
(2002) - et al.
Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics
Schizophr Res
(1997) - et al.
Gabaergic interneuronsImplications for understanding schizophrenia and bipolar disorder
Neuropsychopharmacology
(2001) - et al.
A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressive
Biol Psychiatry
(1998) - et al.
Two-dimensional versus three-dimensional cell counting: A practical perspective
Trends Neurosci
(2001) - et al.
Glutamate decarboxylase(65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain
J Chem Neuroanat
(2000) - et al.
Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects
Neuroscience
(1996) - et al.
The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects
Biol Psychiatry
(2001)
Uncoupling of GABA-A and benzodiazepine receptor binding activity in the hippocampal formation of schizophrenic brain
Brain Res
Expression of calbindin-D28k and parvalbumin during development of rat’s basolateral amygdaloid complex
Int J Dev Neurosci
Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex
Schizophr Res
Stereologic assessment of the total cortical volume occupied by amyloid deposits and its relationship with cognitive status in aging and Alzheimer’s disease
Neuroscience
Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depression
Biol Psychiatry
Schizophrenia and anteroventral thalamic nucleus: Selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons
Psychiatry Res
The rhinal cortices: A wall of inhibition between the neocortex and the hippocampus
Prog Neurobiol
Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia
Neuroscience
Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disordersA review and a Western blot study of synaptophysin, GAP-43 and the complexins
Brain Res Bull
Immunoautoradiographic evidence for a loss of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate-preferring non-N-methyl-D-aspartate glutamate receptors within the medial temporal lobe in schizophrenia
Biol Psychiatry
Neuronal calcium-binding proteins and schizophrenia
Schizophr Res
Limbic pathology in schizophrenia: The entorhinal region- -a morphometric study
Biol Psychiatry
Entorhinal cortex pre-alpha cell clusters in schizophrenia: Quantitative evidence of a developmental abnormality
Biol Psychiatry
Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex
J Chem Neuroanat
Immunohistochemical and immunoblot analysis of gamma-aminobutyric acid B receptor in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
Neurosci Lett
Immunohistochemical and immunoblot study of GABA(A) alpha1 and beta2/3 subunits in the prefrontal cortex of subjects with schizophrenia and bipolar disorder
Neurosci Res
Short-term changes of parvalbumin and calbindin immunoreactivity in the rat hippocampus following cerebral ischemia
Neurosci Lett
Basket-like interneurones in layer II of the enthorinal cortex exhibit powerful NMDA-mediated synaptic excitation
Neurosci Lett
A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia
Biol Psychiatry
Postnatal development of the alpha1 containing GABAA receptor subunit in rat hippocampus
Brain Res Dev Brain Res
Delayed cell death in the contralateral hippocampus following kainate injection into the CA3 subfield
Neuroscience
Coexistence of parvalbumin and GABA in nonpyramidal neurons of the rat entorhinal cortex
Brain Res
Immunohistochemical localization of GABAB receptor in the entorhinal cortex and inferior temporal cortex of schizophrenic brain
Prog Neuropsychopharmacol Biol Psychiatry
Neurobiology of emotion perception II: Implications for major psychiatric disorders
Biol Psychiatry
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Biol Psychiatry
GABAergic neuronal subtypes in the human frontal cortex - development and deficits in schizophrenia
J Chem Neuroanat
Estimation of nuclear population from microtome sections
Anat Rec
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics
Arch Gen Psychiatry
Cytoarchitecture of the entorhinal cortex in schizophrenia
Am J Psychiatry
Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity
Arch Gen Psychiatry
The medial temporal lobe in schizophrenia
J Neuropsychiatry Clin Neurosci
Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions
Am J Psychiatry
Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia
Arch Gen Psychiatry
Manic-like state after bilateral orbitofrontal and right temporoparietal injury: Efficacy of clonidine
Neurology
Pharmacotherapy of psychosis and mania
Measurement of glutamate and glutamine in the medial prefrontal cortex of never-treated schizophrenic patients and healthy controls by proton magnetic resonance spectroscopy
Arch Gen Psychiatry
Altered glutamatergic and GABAergic mechanisms in the cingulate cortex of the schizophrenic brain
Arch Gen Psychiatry
Amygdalo-Entorhinal Inputs to the Hippocampal Formation in Relation to Schizophrenia
Ann N Y Acad Sci
Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients
Arch Gen Psychiatry
Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics
J Neurosci
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