Short CommunicationImpaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice
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Cited by (16)
Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response
2019, Brain ResearchCitation Excerpt :FMRP, the protein product of Fmr1 gene, is expressed across all levels of the central auditory system, including strong expression in the cochlear nucleus and other regions of the brainstem (Zorio et al., 2017). Abnormal functions of these regions in Fmr1 KO mice have been reported (Garcia-Pino et al., 2017; Mott and Wei, 2014; Wang et al., 2018) and both humans with FXS and Fmr1 KO mice show altered ASR and PPI responses (human: Frankland et al., 2004; Yuhas et al., 2011; Hessl et al., 2009; mouse: Chen and Toth, 2001; Nielsen et al., 2002; Renoux et al., 2014; Yun et al., 2006). One of FMRP’s translational targets is matrix metalloproteinase-9 (MMP-9), an endopeptidase important in CNS development through extracellular matrix remodeling and synaptic plasticity (Reinhard et al., 2015).
PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors
2018, Cell ReportsCitation Excerpt :PPI is deficient in SCZ patients and in some other neuropsychiatric disorders and can be measured across different species (Powell et al., 2012; Swerdlow et al., 2008). In an effort to mimic the PPI testing conditions used in patient studies, we recorded PPI using an established protocol with minimal background noise (Renoux et al., 2014). The startle response to a brief loud sound (20 ms, 120 dB) or the response to “analog” (quiet trial, no auditory stimulation) was analyzed.
Influence of Gestational Chlorpyrifos Exposure on ASD-like Behaviors in an fmr1-KO Rat Model
2022, Molecular NeurobiologyFMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game
2021, Frontiers in Molecular Biosciences
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These authors contributed equally to this work.