Short communicationFocal lesions within the ventral striato-pallidum abolish attraction for male chemosignals in female mice
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Acknowledgement
Funded by the Spanish Ministry of Education and Science-FEDER (BFU2007-67912-C02-01/BFI and BFU2010-16656). The authors thank Amparo Novejarque, Nicolás Gutiérrez-Castellanos, Joana Martínez-Ricós and Marcos Otero-García for fruitful discussion on an earlier version of this report, and María José Cano-Cebrián for technical assistance.
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2021, Current BiologyCitation Excerpt :First, we investigated whether activating the neural representation of pleasant odorants could be rewarding, and we found that optogenetic activation of pOB can serve as reinforcer using a self-stimulation paradigm, a widely used operant conditioning to assess the biological bases of motivation.10,11 Second, we explored the underlying neural circuitry downstream of the OB and focused more particularly on the olfactory tubercle (OT), a direct target of the OB that is a component of the ventral striatum12,13 and plays a role in motivated behaviors.14–16 In this context, using 3D high-resolution imaging, electrophysiology, and cellular mapping and optogenetics, we deciphered the anatomical link between the pOB and the OT and revealed that stimulation of the pOB by spontaneously attractive odorants activates the OT and triggers motivated behaviors.
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2020, AppetiteCitation Excerpt :Furthermore, atypical increased activation in the globus pallidus and connected regions in the striatum, thalamus, and frontal cortex have also been reported to be linked to compulsive behaviours in OCD (Rotge et al., 2008). These findings appear to fit well with preclinical findings reporting that the posterior parts of the globus pallidus has a key role supporting and facilitating habitual, rigid behaviours (Agustín-Pavón et al., 2014; McFarland & Kalivas, 2001; Saga et al., 2016; Sommer et al., 2014). Therefore, further investigation of the functional connectivity of the posterior globus pallidus and its role in illness maintenance in AN would be of interest.