Elsevier

Behavioural Brain Research

Volume 213, Issue 2, 1 December 2010, Pages 323-327
Behavioural Brain Research

Short communication
The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

https://doi.org/10.1016/j.bbr.2010.05.008Get rights and content

Abstract

The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.

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Acknowledgements

This research was supported by a grant from the Health Research Council of New Zealand. We also thank S. Illingworth for her involvement.

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      In the context of ASD and schizophrenia, the two disorders most commonly linked with MIA, these findings are more similar to reports of no change in PPI in ASD (Ebishima et al., 2019; Madsen et al., 2014; Oranje et al., 2013; Takahashi et al., 2016) as opposed to the overwhelming evidence of PPI disruptions in schizophrenia (Csomor et al., 2009; Hammer et al., 2011; Swerdlow et al., 2018, 2014). The lack of PPI disruption in our study is in contrast to previous reports of decreased PPI in GD9.5 (Meehan et al., 2017; Meyer et al., 2008; Vuillermot et al., 2011) and GD14.5 (Luchicchi et al., 2016; Wolff and Bilkey, 2010; Zhang and van Praag, 2015) poly I:C studies. However, there are also numerous reports of no changes in PPI for either GD (Abazyan et al., 2010; Ballendine et al., 2015; Chou et al., 2015; Gray et al., 2019; Lipina et al., 2013; Missault et al., 2014; Vorhees et al., 2012).

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