Short communicationNucleus accumbens acetylcholine and food intake: Decreased muscarinic tone reduces feeding but not food-seeking
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Acknowledgements
This work was supported by a Wake Forest University Summer Undergraduate Fellowship (to KB) and the Wake Forest University Department of Psychology. We would like to thank Dr. Federico Bermúdez-Rattoni for advice on preparing AFDX-116, and Dr. Terry D. Blumenthal for his comments on the manuscript. We also thank Dr. Brian A. Baldo and Michelle L. Perry for their valuable intellectual discourse regarding these experiments.
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2018, Journal of Chemical NeuroanatomyCitation Excerpt :The Acb is a crucial component of the so-called reward circuit, receiving dopaminergic inputs from the ventral tegmental area, signaling predictive reward (Rodriguez-López et al., 2017; Schultz, 1998), and projecting to regions that modulate motor output, such as the VP and the substantia nigra (Heimer et al., 1991). Several studies have confirmed the participation of Acb cholinergic interneurons in several processes, such as memory, modulation of appetitive learning, performance, and regulation of mood and motivation (Pratt and Blackstone, 2009; Pratt and Kelley, 2004; Warner-Schmidt et al., 2012). Cholinergic neurons in the CP and GP represent the main source of ACh in the striatum, which plays a crucial role in the control of voluntary movements.
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2018, Pharmacology Biochemistry and BehaviorMurine genetic variance in muscarinic cholinergic receptor antagonism of sucrose and saccharin solution intakes in three inbred mouse strains
2017, Pharmacology Biochemistry and BehaviorCitation Excerpt :Avena and Rada (2012) have implicated acetylcholine (Ach), and particularly its muscarinic receptor, in the mediation of food intake in rats, particularly the “addictive” aspects of excessive sugar intake, by its interactions with brain DA systems. Thus, such potential interactions upon feeding behavior has been observed in the nucleus accumbens (NAC), ventral tegmental area (VTA) and ventral hippocampus (Carballo-Marquez et al., 2009; Nunes et al., 2013; Perry et al., 2009; Pratt and Blackstone, 2009; Pratt et al., 2007; Sharf and Ranaldi, 2006). Our laboratory (Rotella et al., 2015) recently demonstrated that systemic administration of muscarinic receptor antagonism with scopolamine (SCOP) eliminated the acquisition, but minimally inhibited the expression of fructose-conditioned flavor preferences.