Elsevier

Behavioural Brain Research

Volume 197, Issue 1, 30 January 2009, Pages 225-229
Behavioural Brain Research

Short communication
Muscarinic receptor antagonism causes a functional alteration in nucleus accumbens μ-opiate-mediated feeding behavior

https://doi.org/10.1016/j.bbr.2008.08.002Get rights and content

Abstract

Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 μg/0.5 μl), markedly reduced fat intake elicited by intra-Acb treatment of the μ-opioid receptor agonist, DAMGO, with 30 min and 4 h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.

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Acknowledgements

This research was supported by grants from National Institute on Drug Abuse (R01 DA009311, R37 DA004788, and F31 DA023775-01A1) and National Institute of Mental Health (R01 MH074723).

We thank Dr. Wayne Pratt for his intellectual contribution to the development of these studies.

We would like to dedicate this manuscript to the memory of Professor Ann E. Kelley, who died in August 2007.

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    1

    Tel.: +1 608 262 5392; fax: +1 608 265 3050.

    2

    Tel.: +1 608 263 3148.

    3

    Unfortunately, Dr. Kelley passed away last August. While this paper was written after her death, the bulk of the work was carried out while she was still alive, under her supervision.

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