Identity and function of a cardiac mitochondrial small conductance Ca2+-activated K+ channel splice variant
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Abbreviations
APD
action potential duration
BSA
bovine serum albumin
CaMBD
Ca2+ calmodulin binding domain
COX
cytochrome c oxidase
CYPPA
N-cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
DCEB
5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one
EDHF
endothelial hyperpolarizing factor
HR
hypoxia/reoxygenation
EBIO
1-ethyl-2-benzimidazolinone
EGFP
enhanced green fluorescent protein
IMM
inner mitochondrial membrane
IR
ischemia/reperfusion
LAD
left anterior descending coronary artery
mKHE
mitochondrial K+/H+ exchange
ΔΨm
mitochondrial membrane potential
mPTP
mitochondrial permeability transition pore
MCU
mitochondrial Ca2+ uniporter
MTR
mitotracker red
NS8593
N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride
PPC
pharmacological pre-conditioning
RCI
respiratory control index
ROS
reactive oxygen species
RT-PCR
reverse transcription polymerase chain reaction
SKCa
small conductance Ca2+-activated K+ channel
TTC
2,3,5-triphenyltetrazolium chloride
TBAP
Mn(III) tetrakis (4-benzoic acid) porphyrin
TMRM
tetramethylrhodamine
TUNEL
terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling
UCL 1684
6,10-diaza-3(1,3)8,(1,4)-dibenzena-1,5(1,4)-diquinolinacy clodecaphane
Keywords
Cardiac mitochondria
Inner mitochondrial membrane
Cell signaling
Ischemia reperfusion injury
Oxidant stress
Small conductance Ca2+-sensitive K+ channel
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Present address: Department of Surgical Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Published by Elsevier B.V.