Chapter 3 - Cortico-hippocampal systems involved in memory and cognition: the PMAT framework
Section snippets
Anatomical and Functional Connectivity of the PM and AT Systems
The foundation of the PMAT framework is an extensive body of literature documenting differences in anatomical connectivity among MTL structures (Aggleton, 2011, Burwell, 2000, Kondo et al., 2005; see Ranganath and Ritchey, 2012 for review). The PHC is extensively interconnected with both the PRC and RSC, but PHC and RSC show highly overlapping patterns of cortical and subcortical connectivity that diverge from the PRC. The PHC and RSC are major targets of the cingulum bundle, a white matter
Relationship Between Connectivity and Function
A core assumption of the PMAT framework is that connectivity and task function are intimately related; that is, the function of its region will be constrained by its connectivity with other structures, sometimes referred to as its “connectional fingerprint” (Passingham et al., 2002). In one recent study, we directly tested whether the PMAT framework could explain the recruitment of different cortical areas during memory encoding (Ritchey et al., 2014). Using a data-driven, graph theoretic
Roles of the PM and AT Systems in Memory and Cognition
The work described above demonstrates clear links between connectivity and function within the PM and AT systems. Here, we will summarize evidence regarding the kinds of tasks that tend to recruit these systems, focusing first on the PHC, RSC, and PRC (those cortical areas most closely affiliated with the hippocampus), and then considering how these differences extend to other components of the PM and AT systems.
The Hippocampus
Perhaps not surprisingly, the PM and AT systems must work together in order to support the full complement of memory-guided behavior. The hippocampus is a clear point of connection between the two systems due to its strong connectivity with both systems. As noted above and in Fig. 2, there are parallel cortico-hippocampal pathways linking the PM and AT systems with the entorhinal cortex, CA1, and subiculum (Witter et al., 2000). The dentate gyrus is a major convergence point within the
Conclusions
Adopting the PMAT framework encourages one to think about the hippocampus not as an endpoint, but as a critical interface between two cortical systems that contribute to cognition in fundamentally different ways. These contributions can be understood as the product of complex interactions between brain areas, constrained by anatomy and optimized to support rapid learning in the service of perception, action, and cognition. Although the PMAT framework can explain an extensive body of evidence,
References (146)
- et al.
Hippocampal and subicular efferents and afferents of the perirhinal, postrhinal, and entorhinal cortices of the rat
Behav. Brain Res.
(2013) - et al.
Functional-anatomic fractionation of the brain's default network
Neuron
(2010) - et al.
Contributions of episodic retrieval and mentalizing to autobiographical thought: evidence from functional neuroimaging, resting-state connectivity, and fMRI meta-analyses
NeuroImage
(2014) - et al.
TMS evidence for a selective role of the precuneus in source memory retrieval
Behav. Brain Res.
(2015) - et al.
Prefrontal pathways target excitatory and inhibitory systems in memory-related medial temporal cortices
NeuroImage
(2011) - et al.
Positional firing properties of postrhinal cortex neurons
Neuroscience
(2003) - et al.
Functional neuroimaging of autobiographical memory
Trends Cogn. Sci.
(2007) Item, context and relational episodic encoding in humans
Curr. Opin. Neurobiol.
(2006)- et al.
Imaging recollection and familiarity in the medial temporal lobe: a three-component model
Trends Cogn. Sci.
(2007) - et al.
Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat
Behav. Brain Res.
(1996)
Parahippocampal and retrosplenial contributions to human spatial navigation
Trends Cogn. Sci.
The role of medial prefrontal cortex in memory and decision making
Neuron
Are the dorsal and ventral hippocampus functionally distinct structures?
Neuron
Pathways for emotion: interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey
Neuroscience
Going beyond LTM in the MTL: a synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception
Neuropsychologia
Perirhinal cortex supports encoding and familiarity-based recognition of novel associations
Neuron
Hippocampal activity patterns carry information about objects in temporal context
Neuron
Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks
Neuron
Perceptual deficits in amnesia: challenging the medial temporal lobe ‘mnemonic’ view
Neuropsychologia
Semantic memory and the brain: structure and processes
Curr. Opin. Neurobiol.
The role of the ventromedial prefrontal cortex in memory consolidation
Behav. Brain Res.
Impaired object recognition with increasing levels of feature ambiguity in rats with perirhinal cortex lesions
Behav. Brain Res.
Beyond the edges of a view: boundary extension in human scene-selective visual cortex
Neuron
Long-axis specialization of the human hippocampus
Trends Cogn. Sci.
Multiple anatomical systems embedded within the primate medial temporal lobe: implications for hippocampal function
Neurosci. Biobehav. Rev.
Episodic memory, amnesia, and the hippocampal-anterior thalamic axis
Behav. Brain Sci.
Why do lesions in the rodent anterior thalamic nuclei cause such severe spatial deficits?
Neurosci. Biobehav. Rev.
Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition
Behav. Neurosci.
Topographical disorientation: a synthesis and taxonomy
Brain
Comparison of the effects of damage to the perirhinal and parahippocampal cortex on transverse patterning and location memory in rhesus macaques
J. Neurosci.
Memory for spatial location and object-place associations are differently processed by the hippocampal formation, parahippocampal areas TH/TF and perirhinal cortex
Hippocampus
Topographically specific hippocampal projections target functionally distinct prefrontal areas in the rhesus monkey
Hippocampus
Functional specialization in the human medial temporal lobe
J. Neurosci.
Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: effects of viewpoint
Hippocampus
Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys
Hippocampus
Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization
J. Neurosci.
Parietal lobe and episodic memory: bilateral damage causes impaired free recall of autobiographical memory
J. Neurosci.
The hippocampus and memory: insights from spatial processing
Nat. Rev. Neurosci.
Memory deficits characterized by patterns of lesions to the hippocampus and parahippocampal cortex
Ann. N.Y. Acad. Sci.
Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus
Proc. Natl. Acad. Sci. USA
The parahippocampal region: corticocortical connectivity
Ann. N.Y. Acad. Sci.
Perirhinal cortex resolves feature ambiguity in complex visual discriminations
Eur. J. Neurosci.
The perceptual-mnemonic/feature conjunction model of perirhinal cortex function
Q. J. Exp. Psychol. B
Brain activity underlying encoding and retrieval of source memory
Cereb. Cortex
Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys
J. Comp. Neurol.
Object-specific semantic coding in human perirhinal cortex
J. Neurosci.
Anterior and posterior MTL networks in aging and MCI
Neurobiol. Aging
A broader view of perirhinal function: from recognition memory to fluency-based decisions
J. Neurosci.
Medial temporal lobe activity during source retrieval reflects information type, not memory strength
J. Cogn. Neurosci.
Aversive learning modulates cortical representations of object categories
Cereb. Cortex
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