Chronic l-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats

doi:10.1016/S0304-3940(99)00762-4

Neuroscience Letters

Volume 276, Issue 2, 3 December 1999, Pages 71-74

https://doi.org/10.1016/S0304-3940(99)00762-4 Get rights and content

Abstract

The effect of a unilateral 6-hydroxydopamine (6-OHDA) lesion of the left medial forebrain bundle and 3 weeks treatment with l-DOPA of normal and 6-OHDA lesioned rats on CB1r mRNA expression was investigated by in situ hybridization. A 6-OHDA lesion of nigrostriatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mRNA, did not alter CB1r mRNA levels in the dopamine depleted striatum. Similarly, chronic l-DOPA treatment of normal rats had no effect on striatal CB1r mRNA expression. In contrast, chronic l-DOPA treatment of 6-OHDA-lesioned rats significantly increased CB1r mRNA expression in the denervated striatum. These results suggest that the CB1r activity may be altered by l-DOPA's action and this may be related to the treatment of Parkinson's disease.

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Acknowledgements

This work was supported by the National Parkinson Foundation, USA and the Parkinson's Disease Society, UK. B.-Y. Z. and S.R. are the recipients of the National Parkinson Foundation Fellowships.

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Chronic l-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats

Abstract

Section snippets

Acknowledgements

Brain Res.

Mol. Brain Res.

Neuroscience

Neurosci. Lett.

Neuroscience

Neuroscience

Cannabinoid pharmacology

Pharmac. Rev.

A role for cannabinoid receptor stimulation in the treatment of l-DOPA- induced dyskinesia in Parkinson's disease

Mov. Disord.

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

Science

Thrapeutic and adverse effects of l-DOPA. Nanomolar l-DOPA induces basal-glutamate release in intact striata and its augmentation in 6-OHDA-lesioned striata of awake rats

Jpn. J. Pharmacol.