Elsevier

Psychiatry Research

Volume 73, Issues 1–2, 14 November 1997, Pages 109-113
Psychiatry Research

Brief report
Neurotrophin-3 levels in the cerebrospinal fluid of patients with schizophrenia or medical illness

https://doi.org/10.1016/S0165-1781(97)00116-9Get rights and content

Abstract

Neurotrophin-3 (NT-3) may have a potential role in the pathogenesis of schizophrenia, given evidence of abnormal neurodevelopment in schizophrenia, as well as a potential association of an NT-3 gene polymorphism with schizophrenia. Cerebrospinal fluid NT-3 protein was assayed using an enzyme-linked immunosorbent assay in five patients with schizophrenia and 49 patients with medical illness. None of the patients with schizophrenia had detectable levels of NT-3 (above 4.7 pg/ml). Eleven samples from 10 different patients with medical or neurological illness had detectable levels of NT-3, associated with surgery for hydrocephalus or central nervous system infection.

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