Elsevier

The Lancet

Volume 343, Issue 8901, 2 April 1994, Pages 829-830
The Lancet

Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease

https://doi.org/10.1016/S0140-6736(94)92028-1Get rights and content

Abstract

The symptoms of Alzheimer's disease are associated with pathological change and loss of neurons in the medial temporal lobe. By yearly temporal-lobe-oriented computed tomograms the average rate of atrophy of the medial temporal lobe was 15·1% per year (95% Cl 10·0, 20·2) in 20 patients with histopathologically, confirmed Alzheimer's disease and 1·5% (0·2, 2·8) in 47 patients healthy ageing controls. Such excessive atrophy presumably reflects the vulnerability of the medial temporal lobe to a catastrophic event, probably a phatological cascade process. Thus, Alzheimer's disease may not be due simply to an acceleration of normal ageing but, rather, is the consequence of a true disease process.

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