Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease
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Cited by (187)
Widespread severe cerebral elevations of haptoglobin and haemopexin in sporadic Alzheimer's disease: Evidence for a pervasive microvasculopathy
2021, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Here we applied liquid chromatography (LC)-mass spectrometry-based proteomics [16] to relatively quantify protein concentrations in brain tissue in six representative regions from nine sAD cases and nine matched controls. We analysed 18 human brains with short post-mortem delays wherein six anatomically- and functionally-distinct brain regions were examined, of which three are known to undergo severe neuronal damage in sAD (ENT; HP; and cingulate gyrus, CG); two to be moderately affected (sensory cortex, SCX; and motor cortex, MCX); and one (cerebellum, CB) said to be relatively spared [17,18]. We applied mixed hypothesis-generating and pathway-targeted methodologies with Bayesian modelling to quantitate case-control differences in brain levels of nine haemoglobin/iron-relevant proteins.
Cerebral deficiency of vitamin B5 (D-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease
2020, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Here we applied quantitative gas chromatography-mass spectrometry (GC-MS) to determine putative alterations in vitamin B5 concentrations in brain tissue from AD cases and matched controls. We analysed 18 human brains with short post-mortem delay wherein seven anatomically- and functionally-distinct brain regions were examined in each: three of these are known to undergo severe neuronal damage in AD (hippocampus, entorhinal cortex, and middle temporal gyrus); three to be moderately affected (cingulate gyrus, sensory cortex and motor cortex); and one (cerebellum) thought to be relatively spared [14–16]. All experiments were performed in accordance with relevant guidelines and regulations.
Clinical Correlation of Abnormal Findings on Magnetic Resonance Elastography in Idiopathic Normal Pressure Hydrocephalus
2017, World NeurosurgeryCitation Excerpt :Among patients who did not improve after surgery, preoperative MRE demonstrated increased temporal stiffness, possibly suggesting the presence of an unrelated, comorbid neurodegenerative disease. This is particularly likely given that the characteristic pathologic ultrastructural changes in Alzheimer disease include hippocampal atrophy and frontotemporal hypometabolism.34,35 Although our previous results demonstrated a global decrease of parenchymal stiffness in Alzheimer disease, these studies evaluated the cerebrum ROI in isolation, without lobar analysis.19