ArticlePrenatal exposure to morphine alters analgesic responses and preference for sweet solutions in adult rats
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2022, Data in BriefCitation Excerpt :We sought to determine whether early life exposure to morphine that leads to neural tube defects and reward circuitry or social behaviour alterations later in life [3–5] also affects the stability of the circadian system and its sensitivity to light pulses in adulthood.
Maternal morphine intake during pregnancy and lactation affects the circadian clock of rat pups
2021, Brain Research BulletinMaternal Morphine Exposure and Post-Weaning Social Isolation Impair Memory and Ventral Striatum Dopamine System in Male Offspring: Is an Enriched Environment Beneficial?
2021, NeuroscienceCitation Excerpt :Nevertheless, there still are some arguments regarding the impacts of early life MOR exposure on the pain perception in the offspring. In this regard, a study demonstrated that in utero MOR exposure enhanced the antinociceptive effect of MOR following the acute MOR injection in the male and female pups (Gagin et al., 1996). A previous study indicated that the repeated MOR administrations at early infancy have no effect on basal pain threshold during adolescence and adulthood.
Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: The possible role of μ-opioid receptors and ΔFosB in the brain reward pathway
2021, Brain Research BulletinCitation Excerpt :In rodents, μ-opioid receptor mRNA appears in the mesolimbic system as early as gestational day 13 (Georges et al., 1998), indicating possible effects of prenatal μ-opioid receptor agonist administration on receptors development. Animal studies have indicated that prenatal opioids treatment alters responses to both μ-opioid receptor agonist and antagonist in exposed offspring (Gagin et al., 1996; Torabi et al., 2017; Zagon and McLaughlin, 1981). Quality of rearing environment, along with genetics heritability, contributes to individual susceptibility and vulnerability to addiction (Goldman et al., 2006).