Chapter 18 SCN output drives the autonomic nervous system: with special reference to the autonomic function related to the regulation of glucose metabolism

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This chapter describes the role of the suprachiasmatic nucleus (SCN) in the control of the autonomic nervous system with respect to the mechanism of glucose homeostasis. In the effort to elucidate the mechanism of circadian rhythms of food intake and energy metabolism using rats as experimental animals, the chapter finds evidence that the hypothalamic SCN has an important role in the regulation of glucose metabolism through the control of the autonomic nerves. When SCN vasoactive intestinal polypeptide (VIP) neurons receive signals from the circadian oscillator, they may transmit signals for a circadian rhythm to the autonomic functions that include mechanism to maintain glucose homeostasis. When these VIP neurons may receive signals of changes in outer and inner environments, they may produce signals for the alterations in the autonomic nerves and ensure survival, especially in the excitement of sympathetic nervous system related to the elevation of the blood glucose under stressful conditions.

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