Elsevier

International Review of Neurobiology

Volume 41, 1997, Pages 31-38, 38a, 39-60
International Review of Neurobiology

The Cerebrocerebellar System

https://doi.org/10.1016/S0074-7742(08)60346-3Get rights and content

Introduction

If there is a cerebellar contribution to nonmotor function, particularly to cognitive abilities and affective states, then there must be corresponding anatomic substrates that support this. The cerebrocerebellar circuit consists of a feedforward, or afferent limb, and a feedback, or efferent limb. The feedforward limb is composed of the corticopontine and pontocerebellar mossy fiber projections; the feedback loop is the cerebellothalamic and thalamocortical pathways (Fig. 1). Our conceptual approach (Schmahmann, 1991) holds that the cerebellum modifies behaviorally relevant information that it has received from the cerebral cortex via the corticopontine pathway and then redistributes this now “cerebellar-processed” information back to the cerebral hemispheres. For this reason, both limbs (feedforward, and feedback) of this cerebrocerebellar circuit are essential to the discussion of the cerebellar contribution to nonmotor processing.

A second feedforward system links the cerebral cortex with the red nucleus, from where the central tegmental tract leads to the inferior olivary nucleus and then through the climbing fiber system to the cerebellar cortex. This second afferent arc has more restricted relevance to the discussion of the relationship between the cerebellum and cognition. Input from serotonin, norepinephrine and dopamine containing brain stem structures constitutes another substantial source of cerebellar afferents.

This chapter describes the neural circuitry postulated to subserve the cerebellar contribution to nonmotor processing, particularly cognitive and affective modulation. The information presented here is derived from experiments in the nonhuman primate, and whereas there is ample precedent to extrapolate this to an understanding of similar systems in humans, the inherent limitations of this approach are readily acknowledged (cf. H. G. Leiner and A. L. Leiner, this volume).

Section snippets

Corticopontine Projections

The cerebral cortex projection to the basilar pons (the corticopontine pathway) is the obligatory first stage in the feedforward limb of the cerebrocerebellar loop. The corticopontine pathway originates in neurons in layer Vb of the cerebral cortex (Glickstein et al., 1985), the axons of which enter the internal capsule, descend into the cerebral peduncle, and terminate around neurons that occupy the ventral half of the pons. Based in part on its cellular architecture, the basilar pons of the

The Feedback Limb of the Cerebrocerebellar System

The feedback loop of the cerebrocerebellar system is composed of the cerebellar corticonuclear projection, efferents from deep cerebellar nuclei en passant through the red nucleus to the thalamus, and the thalamocortical relay (Fig. 1). The intricacies of the cerebellar cortex itself are beyond the scope of this discussion except to state that elegant models of cerebellar function (Marr, 1969; Albus, 1971; Ito, 1982) have been based on the structural consistency of the cortex and its physiology

Climbing Fibers and Cognition: Is There an Anatomic Substrate?

A central feature of the Marr (1969)-Albus (1971) theory of motor learning is the interaction between mossy fiber and climbing fiber systems. It has been suggested that learning is an important mechanism whereby the cerebellum also modulates nonmotor behavior. Mossy fibers to the cerebellum arise largely from neurons in the basilar pons. The inferior olive is the sole source of the climbing fiber input to the cerebellum. The cerebral afferents of the pontine (mossy fiber) and olivary (climbing

Conclusions

The new understanding of the anatomy of the cerebrocerebellar system presented in this chapter is consistent with the hypothesis that the cerebellum is incorporated into the neural circuitry subserving cognitive and affective operations. The anatomic, circuitry that links the associative and paralimbic cerebral cortices with the cerebellum appears to be directed in both a feedforward and a feedback manner. Those cerebral areas that commit efferents to the cerebellum via the corticopontine

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References (126)

  • O. Oscarsson

    Functional units of the cerebellum: Sagittal zones and microzones

    Trends Nerosci.

    (1979)
  • J.D. Schmahmann et al.

    Prefrontal cortex projections to the basilar pons: Implications for the cerebellar contribution to higher function

    Neurosci. Lett.

    (1995)
  • J.E. Aas et al.

    Demonstration of topographically organized projections from the hypothalamus to the pontine nuclei: An experimental study in the cat

    J. Comp. Neurol.

    (1988)
  • G.I. Allen et al.

    Cerebrocerebellar communication systems

    Physiol. Rav.

    (1974)
  • AnandB.R. et al.

    Cerebellar projections to the limbic system

    J. Neurophysiol.

    (1959)
  • L. Archambault

    Les connexiones corticales du noyau rouge. Nouv. Iconograph

    Salpetr.

    (1914–1915)
  • H. Barbas et al.

    Diverse thalamic projections to the prefrontal cortex in the rhesus monkey

    J. Comp. Neurol.

    (1991)
  • H. Barhas et al.

    Cortical afferent input to the principalis region of the rhesus monkey

    Neuroscience

    (1985)
  • BarbasH. et al.

    Architecture and connections of the prefrontal cortex in rhesus monkey.

  • C.L. Barnes et al.

    Efferent cortical connections of multimodal cortex of the superior temporal sulcus in the rhesus monkey

    J. Comp. Neurol.

    (1992)
  • R.R. Batton et al.

    Fastigial efferent projections in the monkey: An autoradiographic study

    J. Comp. Neurol.

    (1977)
  • G.C. Bayliss et al.

    Functional subdivisions of the temporal lobe neocortex

    J. Neurosci.

    (1987)
  • A.J. Berman et al.

    The effect of cerebellar lesions on ennotional behavior in the rhesus monkey.

  • D. Boussanud et al.

    Visual topography of area TEO in the macaque

    J. Camp. Neurol.

    (1991)
  • J.M. Bower et al.

    Variability in tactile projection patterns to the ccrehcllar folia crus 1IA of the Noway rat

    J Comp. Neural.

    (1990)
  • A. Brodal

    “Neurological Anatomy in Relation to Clinical Medicine.”

    (1981)
  • P. Brodal

    The corticopontine projection in the Rhesus monkey: Origin and principles of organization

    Brain

    (1978)
  • P. Brodal

    The projection from the nucleus reticularis tegmenti pontis to the cerebellum in the rhesus monkey

    Exp. Brain Res.

    (1980)
  • BrodmannK.

    “Vergleichende Lokalisationslehre der Grosshirnrinde in inbren Prinzipien dargestrllt auf Grund des Zellenbaues.”

    (1909)
  • C. Cavada et al.

    Posterior parietal cortex in rhesus monkey. II. Evidence fOr segregated corticocortical network linking sensory and limbic arcas with the frontal lobe

    J. Camp. Nurol.

    (1989)
  • H.M. Cintas et al.

    Some midbrain and dincephalic projections to the inferior olive in the rat.

  • M. Colombo et al.

    Auditory association cortex lesions impair auditory short term memory monkeys

    Science

    (1990)
  • C.W. Dempsey et al.

    Stimulation of the paleocerebellar cortex of the cat: Increased rate of synthesis and release of catecholamines at limbic sites

    Biol. Psychiat.

    (1983)
  • Denny-BrownD. et al.

    The parietal lobe and behavior

    Res. publ. Nerv. Ment. Dis.

    (1958)
  • R. Desimone et al.

    Multiple visual areas in the randal superior temporal sulcus of the macaqne

    J Comp. Neurol.

    (1986)
  • R. Desimone et al.

    Neural mechanisms of visiial processing in monkeys

  • DeVitoJ.L. et al.

    Subcortical projections of the prefrontal lobe or the monkey

    J Comp. Neural.

    (1964)
  • DoreL. et al.

    Organization and postnatal development of Zebrin II antigernc compartmentation in the cerebellar vermis of the grey opossum, Monodelphis domestica

    J. Comp. Nurol.

    (1990)
  • R.S. Dow

    Thc evolution and anatomy of the cerebellum

    Biol. Rev.

    (1942)
  • R.S. Dow

    Some novel concepts of cerebellar physiology

    Mt. Sinni J. Med.

    (1974)
  • R.S. Dow et al.

    “The Physiology and Physiology of the Cerebellum.”

    (1958)
  • F. Eblen et al.

    Highly restricted origin of prefrontal cortical inputs to striosomcs in The macaque monkey

    J. Neurosci.

    (1995)
  • J.C. Eccles et al.

    “The Cerebellum as a Neuronal Machine.”

    (1967)
  • J.M. Fuster

    “The Prefrontal Cortex: Anatomy, Physiology and Neurophysiology of the Frontal Lobe.”

    (1980)
  • A.M. Galaburda et al.

    The intrinsic architectonic and connectional organization of the superior temporal region of the rhesus monkey

    J. COmp. Neurol.

    (1983)
  • N. Geschwind

    Disconnexion syndromes in animals and man. Part I

    Brain

    (1965)
  • N. Geschwind

    Disconnexion syndromes in animals and man. Part II

    Brain

    (1965)
  • M. Giguere et al.

    Mediodorsal nucleus: Areal, laminar, and tangential distribution of afferents and efferene in the frontal lobe of rhesus monkeys

    J. Comp. Neurol.

    (1988)
  • M. Glickstein et al.

    Corticopontine visnal projections in macaque monkeys

    J. Comp. Neurol.

    (1980)
  • M. Glickstein et al.

    Corticopontine projection in the macaque: The distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei

    J. Comp. Neurol.

    (1985)
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