ArticlesAge-Induced Cognitive Alterations in OF1 Mice
Section snippets
Animals
Young 7-week-old (31.5 ± 0.6 g) and old 17–18-month-old (49.5 ± 1.5 g) female OF1 mice from IFFA-CREDO (L’Arbresle, France) were used. The mice grew old in the animal room and were used from 17 months of age when mortality is 50% according to the survival curve. Mice were housed in group cages, six animals of the same age per cage, in an air-conditioned animal room illuminated from 0800–2000 h, and maintained at 21 ± 1°C. They were allowed ad lib access to standard lab diet and water.
Locomotor Activity
The number of photobeam breaks were recorded every 5 min for 60 min. Multivariate analysis of cumulative values for 60 min (Fig. 1A) showed an effect of time, F(11, 198) = 57.5, p < 0.0001, of age, F(1, 18) = 17.33, p < 0.001, and no significant time × age interaction, F(11, 198) = 0.77, p = 0.07. Old mice were less active than young mice.
The number of photobeam breaks was calculated for each 5-min period by subtracting the previous cumulative value (Fig. 1B). The comparison of scores between
Discussion
The present results show that in old OF1 female mice a reduced locomotion and learning/memory ability for each of the four tests used. These results, however, require detailed analysis because of possible bias due to an alteration in the motor or sensory abilities of old mice.
The locomotor activity of old mice was significantly reduced compared to that of young mice. This may reflect impaired physical capacity. Another explanation is that because scores were significantly different only at 5,
Acknowledgements
We thank Didier Fauconnier and Amhed Kébir for the maintenance of animals, and Alan Strickland for reviewing this manuscript. This work was supported by the Institut National de le Santé et de la Recherche Médicale.
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