Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice
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Whole-brain activation signatures of weight-lowering drugs
2021, Molecular MetabolismGlibenclamide restores dopaminergic reward circuitry in obese mice through interscauplar brown adipose tissue
2020, PsychoneuroendocrinologyCitation Excerpt :Moreover, DA can reduce glucose uptake in WAT through ARs (Lee et al., 1998). Accordingly, restoring the dopamine level and coactivating dopamine receptors increase protein mass and reduce triglyceride, free fatty acid, and glucose concentrations in the blood (Cincotta et al., 1997). The hypodopaminergic activity was observed in HFD-fed mice; such activity may be involved in the development of metabolic syndromes such as hyperlipidemia, hyperglycemia, and insulin intolerance (Fig. 1d, 1e and Fig. 2).
Dopamine signaling and myopia development: What are the key challenges
2017, Progress in Retinal and Eye ResearchTesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: Dopamine transporter occupancy as measured by PET
2014, European NeuropsychopharmacologyCitation Excerpt :TE might, however, induce an indirect, long-term effect on DA D2 RA due to enhancing amounts of synaptic DA by blockade of DAT. Both D1 and D2 agonists have been shown to reduce food intake in animal models of obesity (Cincotta et al., 1997; Scislowski et al., 1999; Davis et al., 2009). Further, apparently there occur functional synergistic interactions between D1 and D2 receptor systems in the basal ganglia, which play a critical role in neuronal output, and thus behavioural effects (Walters et al., 1987; Waddington, 1989).
Regulation of prolactin in mice with altered hypothalamic melanocortin activity
2012, PeptidesCitation Excerpt :Furthermore, a positive correlation was reported between Pomc mRNA and tyrosine hydroxylase mRNA in the MBH of the rat suggesting coregulation or functional interaction between these two neuronal systems [32]. Thus there is evidence for bidirectional interactions between the hypothalamic dopamine system and melanocortin pathways that play critical roles in maintaining energy homeostasis [4,12,18,39,42]. This study provides additional evidence to support functional interactions between the hypothalamic melanocortin and dopaminergic systems that may be reflected by plasma prolactin levels.