Rapid communicationBicuculline induces ictal seizures in the intact hippocampus recorded in vitro
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Acknowledgements
We are grateful to Dr. C. Bernard for the fruitful ideas and comments on the manuscript.
References (3)
- Ben-Ari, Y., E. Cherubini, R. Corradetti and J.L. Gaı̈arsa, 1989, Giant synaptic potentials in immature rat CA3...
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GABAergic circuits drive focal seizures
2023, Neurobiology of DiseaseThe postnatal GABA shift: A developmental perspective
2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Hippocampal GDPs increase when GABAergic depolarization is enhanced (Spoljaric et al., 2019). In contrast, hippocampal and cortical GDPs transform into epileptiform discharges after loss of depolarizing GABA (Allène et al., 2008; Ben-Ari et al., 1989; Dzhala et al., 2005; Khalilov et al., 2015, 1997; Leinekugel et al., 1997; Mohajerani and Cherubini, 2005; Pfeffer et al., 2009; Rheims et al., 2008; Sipila et al., 2006; Valeeva et al., 2010; Wells et al., 2000). This is because the action of GABA changes from depolarizing to hyperpolarizing during a GDP cycle due to the large reduction in intracellular Cl− concentration when many GABAA channels open.
The GABA excitatory/inhibitory developmental sequence: A personal journey
2014, NeuroscienceCitation Excerpt :Cell-attached and whole-cell dual recordings of interneurons revealed that interneurons fire bursts of spikes triggered by periodical large inward currents during GDPs, (Fig. 3A, B). These are blocked by TTX and by high divalent cations (6 mM Mg++ and 4 mM Ca++) and can be evoked in an all-or-none manner by electrical stimulation in different regions of the hippocampus (Khazipov et al., 1997; Khalilov et al., 1997b). GDPs can be generated by isolated CA3 subfield of the slice confirming their local generation by a small set of interneurons and pyramidal neurons.
Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus
2014, Epilepsy ResearchCitation Excerpt :In the present study we observed that the activation of GABAA receptors by muscimol suppresses epileptiform activity. This observation corroborates numerous previous reports that demonstrated a general inhibitory action of GABA already in the immature rodent CNS (Baram and Snead, 1990; Khalilov et al., 1997; Wells et al., 2000; Kilb et al., 2007; Richter et al., 2010), although we like to emphasize here that the cellular action of GABA during the early postnatal interval is complex and thus depolarizing GABAergic responses can also contribute to the generation of epileptiform activity (Dzhala and Staley, 2003; Dzhala et al., 2005; Kolbaev et al., 2012). However, we propose from our observation that anticonvulsive effects in general indicate an enhanced GABAergic drive.