Binding of the anti-progestin ru-486 to rat ovary steroid receptors*
References (11)
- et al.
Rat ovary glucocorticoid receptor: identification and characterization
Steroids
(1982) Primary cultures of ovarian cells in serum-free medium as models of hormone-dependent differentiation
Mol. Cell. Endocrinol.
(1983)- et al.
Induction of menstruation by an anti-progesterone (RU 38486) in monkeys
- et al.
RU 38486 - A new lead for steroidal anti-hormones
- et al.
The effect of an antiprogesterone steroid in women: interruption of the menstrual cycle and early pregnancy
Compus Rendus
(1982)
Cited by (67)
Aldosterone Mediated Regulation of Epithelial Sodium Channel (ENaC) Subunits in the Rat Hypothalamus
2018, NeuroscienceCitation Excerpt :RU-28318 used for incubations was 2.5 μM, whereas that of RU-486 was 5 μM. The concentration of these competitive antagonists was determined based on published reports that RU-28318 and RU-486 competitively bind to the receptor with an affinity similar to that of the mineralocorticoid (Janiak and Brody, 1988) and glucocorticoid (Schreiber et al., 1983). The final concentration of DMSO in ACSF was 0.05% when aldosterone or corticosterone was applied and 0.1% when MR or GR antagonists were applied in addition to aldosterone or corticosterone.
Increased ventilation in female erythropoietin-deficient mouse line is not progesterone and estrous stage-dependent
2017, Respiratory Physiology and NeurobiologyCitation Excerpt :As no effects was observed, only treatment with Mifepristone was used in this set of experiments. Mifepristone is a mixed antagonist of progesterone and glucocorticoid receptors, which permits to this synthetic steroid compound to bind with very high affinity to progesterone and glucocorticoid receptors in rats (Schreiber et al., 1983). Furthermore, mifepristone also binds weakly to the androgen receptor and might also have a weak anti-androgenic activity (Schreiber et al., 1983).
Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction
2017, Trends in Endocrinology and MetabolismDifferential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons
2014, Molecular and Cellular EndocrinologyMineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models
2013, European Journal of PharmacologyCitation Excerpt :Consequently, it is unlikely that the anti-inflammatory activities of MR antagonists observed in the current report are mediated by stimulation of GR. In support of this assertion, we were unable to show that the nasal effect of eplerenone was impacted by prior treatment with the GR/PR antagonist, RU486 (Jung-Testas and Baulieu 1983; Schreiber et al., 1983). We speculate that the anti-inflammatory actions of MR antagonists in the respiratory system may be driven by comparable mechanisms that may direct the anti-inflammatory actions of RAAS blockers in the adipose tissues, in the CNS and in the renal and cardiovascular systems (Hu et al., 2005; Pearce et al., 2003; Satofuka et al., 2009; Stegbauer et al., 2009; Montecucco et al., 2009; Gilbert and Brown, 2010; Frieler et al., 2011).
Antagonism of progesterone receptor suppresses carotid body responses to hypoxia and nicotine in rat pups
2012, NeuroscienceCitation Excerpt :However, it appears that mechanisms related to postnatal body growth are under the influence of either the progesterone or corticosteroid receptor and warrants further investigation to be better understood. Mifepristone is a synthetic steroid compound that binds with very high affinity to the rat progesterone and glucocorticoid receptors (Healy et al., 1983a,b; Jung-Testas and Baulieu, 1983; Schreiber et al., 1983; Moguilewsky and Philibert, 1984) forming an inactive complex. This is one of the few available antagonists for these receptors.
- *
Supported by NIH Grant HD-17753, HD-12304d, and the Mother's Aid Research Fund.