Elsevier

Brain Research

Volume 833, Issue 2, 3 July 1999, Pages 291-296
Brain Research

Short communication
In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep–wakefulness

https://doi.org/10.1016/S0006-8993(99)01511-5Get rights and content

Abstract

We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep–waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.

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Acknowledgements

We wish to thank Joyel Almajano for technical assistance, Toan Do and Larry Ackerson for HPLC analysis, and Tony Fields for EEG recording assistance. Faustino Lopez-Rodriguez was supported by a Program in Minority Research Training in Psychiatry Fellowship, funded by NIMH, MH 19126. Funding was provided by NIH grants NS 33310 and NS 02808.

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