Short communicationIn vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep–wakefulness
Section snippets
Acknowledgements
We wish to thank Joyel Almajano for technical assistance, Toan Do and Larry Ackerson for HPLC analysis, and Tony Fields for EEG recording assistance. Faustino Lopez-Rodriguez was supported by a Program in Minority Research Training in Psychiatry Fellowship, funded by NIMH, MH 19126. Funding was provided by NIH grants NS 33310 and NS 02808.
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2023, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6, Second EditionSerotonin receptor antagonists increase fast ripple activity in rats treated with kainic acid
2016, Brain Research BulletinCitation Excerpt :This suggests that FR are an important biomarker of epileptogenesis in temporal lobe epilepsy (TLE) (Zijlmans et al., 2012; Aibel-Weiss et al., 2015) as well as in extratemporal epilepsies (Wang et al., 2013). Events of neuronal synchronization corresponding to the wide band of FR are markedly increased during sleep in comparison with wakefulness, particularly in slow wave sleep (Staba et al., 2004) in which serotonin levels are decreased significantly (Park et al., 1999). Additionally, serotonin has been widely studied as a potential modulator of epileptic activity, with evidence suggesting that using selective serotonin reuptake inhibitors decreases the occurrence of seizures (Bagdy et al., 2007) or inhibition of serotonin activity increases epileptiform activity (Shiha et al., 2015; Cuellar-Herrera et al., 2014).
Sleep deprivation enhances peripheral serotonin secretion to regulate the large follicle steroidogenesis of rats
2015, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :Previous studies have found that serotonin is present in follicular fluid, its receptors and limiting enzyme in serotonin synthesis, tryptophan hydroxylase, is expressed in follicular cells [26–30], which indicate that serotonin could regulate ovarian follicular function. In accordance with previous reports [14,15], it was found that serotonin concentrations were significantly increased following SD; hence, it is possible that the disrupted estrous cycle associated with SD may be part of a consequence of serotonin-related inhibition of estradiol production. Ovaries are innervated with serotonergic nerves and SD could activate the serotonergic nerve system to enhance serotonin release, therefore, serotonin could be permeated through follicular membranes to affect granulosa cells [27].
Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures
2014, Brain ResearchCitation Excerpt :To the best of our knowledge, no in vivo studies have yet sought to identify the factors that modulate FRs via chemical or electrical neurotransmission. In the KA animal model of epilepsy and in TLE patients, abundant FRs have been reported in slow wave sleep, a period during which serotonin levels decrease (Park et al., 1999; Staba et al., 2004). Moreover, the serotonergic system has been implicated in the pathophysiology and treatment of epilepsy (Yan et al., 2012; Statnick et al., 1996).
Effects of sleep deprivation on serum testosterone concentrations in the rat
2011, Neuroscience Letters