Short communicationSubstrate for rapid feedforward inhibition of the auditory forebrain
Section snippets
Note added in proof
The preliminary report cited in [2]has been published: D. Peruzzi, E. Bartlett, P.H. Smith, D.L. Oliver, A monosynaptic GABAergic input from the inferior colliculus to the medial geniculate body in rat, J. Neurosci. 17 (1997) 3766–3777.
Acknowledgements
This research was supported by Public Health Service Grant, R01 DC00726, from the National Institute on Deafness and Other Communication Disorders (NIH).
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Cited by (35)
Mechanisms of GABAergic and cholinergic neurotransmission in auditory thalamus: Impact of aging
2021, Hearing ResearchCitation Excerpt :In the context of understanding how GABAergic inhibition might impact MGB coding properties, it is essential to consider the sources of GABA release and their potential roles in auditory processing in the MGB (Figs. 1A and 2A). First, in addition to a small population of local inhibitory interneurons in rodents (Winer et al., 1999; Winer and Larue, 1996), GABAergic afferents to MGB neurons arise directly from the IC (Bartlett et al., 2000; Bartlett and Smith, 1999; Peruzzi et al., 1997; Saint Marie et al., 1997; Winer et al., 1996). Unfortunately, the specific role of GABAergic projections from IC (bottom-up) and local interneurons in shaping MGB processing and coding properties remains poorly understood, but speculation as to how these projections may contribute to overall tonic GABAAR-mediated inhibition and phasic inhibitory events is discussed below.
Characterization of the human central nucleus of the inferior colliculus
2019, Hearing ResearchCitation Excerpt :At the very least, GAD-IR neurons in the human CNIC would appear to fall within the small to medium-sized neuron range. In other laboratory species, there are large GAD-IR neurons in the CNIC that integrate glutamatergic input from the lemniscal pathway and project to the MG (Saint Marie et al., 1997; Ito et al., 2009; Beebe et al., 2018). These large GABAeric neurons appear to comprise a major source of feedforward inhibition to the MG (Ito et al., 2009; Ito and Malmierca, 2018).
Subtypes of GABAergic cells in the inferior colliculus
2019, Hearing ResearchCitation Excerpt :The difference may be quantitative rather than qualitative; they found that the large cells with dense VGLUT2 inputs outnumbered the small cells without such inputs, whereas we found the smaller cells more numerous. Interestingly, the data from the GABAergic axons in the brachium of the IC indicate that small axons, presumably originating from small cells, are particularly numerous in cats (Saint Marie et al., 1997, Fig. 7). The original study emphasized that the largest axons are all GABAergic.
Auditory thalamic circuits and GABA<inf>A</inf> receptor function: Putative mechanisms in tinnitus pathology
2017, Hearing ResearchCitation Excerpt :The MGB receives lemniscal and extralemniscal ascending inputs as well as inputs from the brainstem, thalamic reticular nucleus, limbic structures and descending inputs from auditory and nonauditory cortices (Fig. 1) (Bajo et al., 1995; Lee & Winer, 2008a, 2008b, 2008c; Rouiller & Ribaupierre, 1990; Rouiller & Welker, 1991; Winer & Larue, 1987; Winer et al., 1999). The ventral division (MGv) is believed to be primarily auditory/lemniscal receiving tonotopically-aligned primary ascending excitatory and inhibitory projections from inferior colliculus (Peruzzi et al., 1997; Saint Marie et al., 1997a). The dorsal (MGd) and medial (MGm) divisions of the MGB show poor tonotopic order and are considered non-lemniscal (see Bartlett, 2013), receiving inputs from the non-tonotopically organized regions of the inferior colliculus (Calford & Aitkin, 1983) as well as driver-like input from the auditory cortex (Llano & Sherman, 2008).