Neuron
ArticleAlterations in the expression and gating of drosophila sodium channels by mutations in the para gene
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The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila
2016, Current BiologyCitation Excerpt :Silencing CII and CIII neurons together (Figure S3E) resulted in mild to equivalent reductions in cold responses in the plate or probe assays, respectively, versus silencing CIII alone (Figure S4). As an alternative approach, we interfered with the para gene, which encodes an NaV-type sodium channel, to block action potential propagation in CIII neurons [35, 36]. This blocked cold-induced CT in both assays (Figures 4C and 4D).
Movement disorders in drosophila mutants of potassium channels and biogenic amine pathways
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2004, Movement Disorders: Genetics and Models: Second EditionHyper-susceptibility to deltamethrin in para<sup>ts-1</sup> DDT resistant Drosophila melanogaster
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2003, Methods in Cell BiologyCitation Excerpt :A disadvantage of traditional “Seecof-type” cultures is that neurons are small (∼4 μm in diameter) and fragile. However, with whole cell patch-clamp recording, it is feasible to examine voltage-gated ion channels in these cultured neurons (Byerly and Leung, 1988; O'Dowd and Aldrich, 1988; Leung et al., 1989; O'Dowd et al., 1989; Germeraad et al., 1992; Tsunoda and Salkoff, 1995). Mutations that eliminate or severely reduce the function of essential neuronal genes result in embryonic lethality.
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Present address: Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California 92717.