Neuron
N-cadherin and integrins: Two receptor systems that mediate neuronal process outgrowth on astrocyte surfaces
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Graphene oxide substrates with N-cadherin stimulates neuronal growth and intracellular transport
2019, Acta BiomaterialiaCitation Excerpt :Cadherins, in particular, are cell–cell adhesion proteins which associate with catenin and interact with the actin cytoskeleton [8–10]. N-cadherin is essential for the functional organization of adult neural tissue and the development of neural networks by mediating axon guidance [11], neurite outgrowth [12–14], dendritic arborizations [9], and synaptogenesis [15,16], all of which require actin polymerization at the growth cones [17]. In addition, studies demonstrate that the function of N-cadherin can be recapitulated in vitro [18].
Glial Dysregulation in Addiction
2018, Neural Mechanisms of AddictionTherapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury
2015, Brain ResearchCitation Excerpt :In this way, they regulate axon outgrowth during development and after injury. Laminin, N-cadherin, neural cell adhesion molecules (NCAM) and fibronectin are some of these growth-promoting molecules (Liesi et al., 1983; Liesi and Silver, 1988; Neugebauer et al., 1988; Price and Hynes, 1985; Tomaselli et al., 1988). On the other hand, inhibitory proteoglycans serve as negative guidance cues for axon growth, and their expression by astrocytes is increased following SCI (Gonzalez Mde et al., 1993; Snow et al., 1990).
Cadherin-based transsynaptic networks in establishing and modifying neural connectivity
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2020, Biotechnology AdvancesCell adhesion and matricellular support by astrocytes of the tripartite synapse
2018, Progress in NeurobiologyCitation Excerpt :N-cadherin functions at both pre- and postsynaptic sites, where it spans the synaptic cleft by forming predominantly homophilic bonds (Missler et al., 2012). Its expression inhibits neurite outgrowth of embryonic chick ciliary ganglia neurons grown on a cortical astrocyte monolayer (Tomaselli et al., 1988), a finding that is confirmed in mature rat hippocampal neurons (Saglietti et al., 2007). Binding of N-cadherin to GluA2 subunits of glutamate receptors in the synapse promotes spine morphogenesis and presynaptic maturation via the N-terminal domain of GluA2, and the recruitment of GluA2 at the synapse induces further N-cadherin accumulation in the synapse (Saglietti et al., 2007).