ArticleChronic prenatal methadone exposure alters central opioid μ-receptor affinity in both fetal and maternal brain
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Effects of opioids on the parental brain in health and disease
2019, Frontiers in NeuroendocrinologyCitation Excerpt :For mothers with OUD, adaptative parenting behaviors depend on their perceived parenting stress (Suchman and Luthar, 2001), which depends on how well they can emotional attune to the child’s psychological needs (Borelli et al., 2012). It is well known that gestational opioid exposure results in alterations in opioid receptor binding and functionality in dams during pregnancy and the early postpartum (Hou et al., 2004; Darmani et al., 1992), however only a few comparative studies have investigated the effects of opioids on a parental brain compared to a virgin or non-postpartum brain. Though changes in pharmacokinetics and thus plasma and tissue distribution of opioids are well established during pregnancy (Shah et al., 1976), the effects of these changes on the maternal brain are not well documented.
Child neuroanatomical, neurocognitive, and visual acuity outcomes with maternal opioid and polysubstance detoxification
2015, Pediatric NeurologyCitation Excerpt :However, the lower visual acuity in part observed in the risk group gives reason for concern because vision problems have repeatedly been shown in opioid-exposed children.43,44 Animal studies have shown detrimental effects of prenatal methadone on neurotransmitters and mu-receptor affinity45,46 that may have adverse effects on vision. In a recent report, summed raw scores for picture completion and vocabulary did not deviate across a group of OMT- and nicotine-exposed 4 year olds relative to a comparison group.47
Endogenous opiates: 1992
1993, PeptidesPrenatal exposure to methadone or buprenorphine alters µ-opioid receptor binding and downstream signaling in the rat brain
2020, International Journal of Developmental Neuroscience
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Present address: Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO 63501.