The acoustic startle response in DBA/2 and C57BL/6 mice: relationship to auditory neuronal response properties and hearing impairment
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Cited by (58)
Increasing GABA reverses age-related alterations in excitatory receptive fields and intensity coding of auditory midbrain neurons in aged mice
2017, Neurobiology of AgingCitation Excerpt :There is still a debate over whether there is a clearly defined set of eFRA types, or if some neurons exhibit responses that are intermediate classifications or contain characteristics of several of these based on their inhibitory and excitatory projections (Palmer et al., 2013). For this study, we settled on a set of classification types similar to those described in a study by Willott et al., without categorizing every possible continuum (Willott et al., 1984). Previous reports have shown that systemic administration of VGB can reduce tinnitus and improve temporal processing, identified using behavioral measures in rodents (Brozoski et al., 2007; Gleich and Strutz, 2011; Gleich et al., 2003, 2014).
Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential
2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Age-related changes in PPI strength depend on the prestimulus conditions in C57BL/6J mice. Tone pulse PPI remains robust except for high frequencies (Fig. 6B) (Willott et al., 1984; Willott and Turner, 1999), but noise-offset PPI declines rapidly after one month of age in this strain (Fig. 6C) (Ison et al., 1998). CBA/CaJ and CBAxC57 hybrid mice also show age-related decline in noise offset PPI, but at different timecourses (Fig. 6C) (Ison et al., 1998).
Genetic Models of Reflex Epilepsy and SUDEP in Rats and Mice
2017, Models of Seizures and Epilepsy: Second EditionThe effect of progressive hearing loss on the morphology of endbulbs of Held and bushy cells
2017, Hearing ResearchCitation Excerpt :To characterize the effects of acquired progressive hearing loss on EB and BC structure, we utilized the DBA/2 mouse, a strain that exhibits early-onset sensorineural hearing loss. DBA/2 mice begin to display high-frequency hearing loss at 3–4 weeks of age, shortly after hearing onset (P11; Ehret, 1976) and just before sexual maturity (6–7 wks; Green and Witham, 1991); this loss progresses into adulthood to include the remaining mid-to-low frequencies (Henry and Haythorn, 1975; Hultcrantz and Spangberg, 1997; Johnson et al., 2000; Shin et al., 2010; Willott and Erway, 1998; Willott et al., 1984; Zheng et al., 1999). The pattern of hearing loss of the DBA/2 is closely paired to a progressive loss of inner and outer hair cells (Hultcrantz and Spangberg, 1997), and has been attributed to mutations in two separate proteins—cadherin-23 (Noben-Trauth et al., 2003) and fascin-2 (Shin et al., 2010)—associated with stereocilia stability and function.
Electrical stimulation of the dorsal cochlear nucleus induces hearing in rats
2010, Brain ResearchCitation Excerpt :That is, the acoustic startle reflex responses are suppressed when an animal hears an acoustic prepulse signal. It has previously been demonstrated that the degree of aPPI correlates with the level of the acoustic prepulse signals (Barsz et al., 2002; Willott et al., 1984; Willott et al., 1994; Young and Fechter, 1983). In addition, it has been reported that the aPPI paradigm can be used to detect different frequencies of acoustic prepulse signals (Willott et al., 1994), and the results are comparable to those determined by operant behavioral paradigms (Young and Fechter, 1983).
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Present address: Department of Psychology, Carthage College, Kenosha, WI 53140, U.S.A.