ArticleGlial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo
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Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice
2020, Molecular Therapy Methods and Clinical DevelopmentUpdate of neurotrophic factors in neurobiology of addiction and future directions
2017, Neurobiology of DiseaseCitation Excerpt :Both GDNF and NRTN can protect and restore the nigrostriatal dopamine circuitry in animal models of PD, and they have been tested in human clinical trials for PD, with variable and mainly disappointing results (Rangasamy et al. 2010). In the intact rodent brain, GDNF boosts the dopaminergic function by increasing dopamine turnover, augmenting stimulus-induced dopamine release, as well as inducing sprouting of tyrosine hydroxylase-reactive fibers (Cass et al. 1999; Hebert et al. 1996; Hudson et al. 1995). Although the most intriguing effect of BDNF in the intact CNS may be its role in regulating long term potentiation (LTP) (Kang and Schuman 1995; Lohof et al. 1993), infusion of BDNF into intact rat brain also increases dopamine turnover, induces contralateral rotations after amphetamine administration, and affects the firing rate and number of spontaneously active dopamine neurons (Altar et al. 1992; Shen et al. 1994).
Biology of GDNF and its receptors — Relevance for disorders of the central nervous system
2017, Neurobiology of Disease