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2023, NeuroscienceCitation Excerpt :We have identified other phosphorylated proteins in the cytoplasmic granules such as MAP2-P Thr1620/1623, MAP1B-P Thr1265, ADD1-P Ser726, and ADD1/ADD1-P Ser726/Ser713. Several phosphorylated kinases are expressed in subsets of neurons with pre-tangles and NFTs (Arendt et al., 1995; Perry et al., 1999; Hensley et al., 1999; Pei et al., 1999; Zhu et al., 2000; Zhu et al., 2001a,b; Zhu et al., 2002; Pei et al., 2001; Atzori et al., 2001; Ferrer et al., 2001a,b; Pei et al., 2002a,b; Ferrer et al., 2002; Sun et al., 2003; Ferrer, 2004; Ferrer et al., 2005). The expression of such active kinases is accompanied by the activation of the corresponding upstream activators in neurons with NFTs (Arendt et al., 1995; Ferrer et al., 2001a,b; Zhu et al., 2001c, Pei et al., 2002a,b; Zhu et al., 2003a, Zhu et al., 2003b).
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