Capsaicin treatment induces selective sensory degeneration and increased sympathetic innervation in the rat ureter
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Involvement of the peripheral sensory and sympathetic nervous system in the vascular endothelial expression of ICAM-1 and the recruitment of opioid-containing immune cells to inhibit inflammatory pain
2010, Brain, Behavior, and ImmunityCitation Excerpt :During the early phase of inflammatory pain (6 h FCA) predominantly opioid peptide-containing PMNs (i.e., granulocytes) immigrate into inflamed subcutaneous tissue, whereas, during the late phase of inflammatory pain (4 days FCA) mononuclear cells (70–75% monocytes/macrophages, <5% lymphocytes) prevale (Rittner et al., 2001; Machelska et al., 1998, 2003; Mousa et al., 2000). In the first part of this study, we investigated the potential role of the peripheral sensory nervous system in the recruitment of opioid peptide-containing leukocytes by capsaicin treatment, a neurotoxin that selectively destroys sensory nerves (Barthó et al., 1990; Holzer et al., 1991; Sann et al., 1995). It is well established that the neurotoxic effect of capsaicin is dose dependent: low doses of capsaicin cause depletion of neuropeptides such as CGRP and substance P, however, high doses of 50–100 mg/kg – even already a single injection – causes substantial degeneration of sensory neurons within the spinal cord, dorsal root ganglion and peripheral subcutaneous tissue (reviewed by Holzer et al. (1991)).
Plasticity of nodose ganglion neurons after capsaicin- and vagotomy-induced nerve damage in adult rats
2010, NeuroscienceCitation Excerpt :First, capsaicin treatment may evoke sprouting of undamaged capsaicin-insensitive (VR1−) nerve fibers. Indeed, Sann et al. (1995) reported that in the rat ureter, the loss of capsaicin-sensitive afferents was followed by sprouting of neuropeptide Y– and dopamine beta hydroxylase–containing non-sensory nerve fibers resulting in hyper-innervation. Second, it was recently shown that a large neuronal replacement may occur in NG of adult rats after capsaicin-induced destruction (Czaja et al., 2008).
The mechanisms of the inhibitory effect of ethanol on gastric emptying involve type a CCK receptors
2004, Regulatory PeptidesVanilloid receptor 1 expression in the rat urinary tract
2002, NeuroscienceInvolvement of NGF in the induction of increased noradrenergic innervation of the ureter in neonatally capsaicin-treated rats
1998, Journal of the Autonomic Nervous System