The nuclei of origin of brain stem enkephalin and substance P projections to the rodent nucleus raphe magnus
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Cited by (125)
5.16 - Descending Control Mechanisms
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionAnalgesic and anti-edematogenic effects of oral trypsin were abolished after subdiaphragmatic vagotomy and spinal monoaminergic inhibition in rats
2016, Life SciencesCitation Excerpt :The nucleus of the solitary tract (NTS) receives visceral afferent inputs from the vagus nerve, and sends connections to the medulla. This last station, in its turn, sends aminergic projections to the spinal cord [43–45]. Such projections are important modulators of spinal nociceptive processing [46–50] and, indeed, vagal stimulation has been shown to produce either analgesic [9–11] or anti-inflammatory effects [7,8], in which medullary substrates were shown to play an important role [12,13].
Changes in the disposition of substance P in the rostral ventromedial medulla after inflammatory injury in the rat
2016, NeuroscienceCitation Excerpt :These experiments revealed an increase in the density of SubP immunoreactivity in the RVM, localized to processes and puncta, four h and four days, but not two weeks after CFA. SubP containing axon terminals and varicosities in the RVM originate from neurons in the nucleus cuneiformis, dorsal raphe nucleus, and PAG (Beitz, 1982; Chen et al., 2013). The most obvious explanation for the increase in SubP immunoreactive processes and puncta in the RVM is an increased synthesis of SubP in PAG and cuneiform neurons.
Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing
2013, Journal of PainCitation Excerpt :Meanwhile, more than half of (51.4%) of the 5-HT/GABA double-labeled neurons contain NK-1R. By utilizing horseradish peroxidase tracing combined with immunohistochemistry, it has been demonstrated previously that the central origins of SP-ir projections to the rat RVM come mainly from the CnF, PAG, nucleus of the solitary tract, superior central raphe nucleus, and the nucleus pontis oralis.5 In the present study, we found that SP/FG double-labeled neurons are restricted in the CnF, LPAG, and DR. This difference may come from the different tracers and different species of animal.
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Present Address: Department of Veterinary Biology, University of Minnesota, 1988 Fitch Avenue, St. Paul, MN 55108, U.S.A.