Localization of the antinociceptive and antianalgesic effects of neurotensin within the rostral ventromedial medulla
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Cited by (41)
Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats
2011, Journal of PainCitation Excerpt :There is evidence that neurons in this area mediate other homoeostatic functions besides pain.12,36,52,58,67 Additionally, the RVM may serve as a relay output for effects of the locus coeruleus.48,53,66,76 Indeed, lesions of the locus coeruleus (LC) have been shown to decrease physical signs of opioid withdrawal,33 and electrical stimulation of this nucleus or direct injection of opioid antagonists into the locus coeruleus precipitate the expression of opiate withdrawal.16,29
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray
2011, Brain ResearchCitation Excerpt :Electrical stimulation of PAG is known to induce analgesia both in humans and animals (Mayer, 1984; Reynolds, 1969). The PAG plays a key role in the descending modulation of nociception by projecting via the rostral ventromedial medulla to spinal cord dorsal horn neurons (Liebeskind et al., 1973; Moreau and Fields, 1986; Urban and Smith, 1994). Previous studies have suggested that the PAG is also an important site for endocannabinoid-mediated analgesia (Hohmann et al., 2005; Maione et al., 2006).
Altered morphine-induced analgesia in neurotensin type 1 receptor null mice
2010, NeuroscienceCitation Excerpt :Our results based on a genetic approach are also in apparent contradiction with previous pharmacological findings. Indeed, administration of the NT receptor antagonists, [D-Trp11] NT or SR48692 into the RVM has been shown to potentiate the development of morphine analgesia (Urban and Smith, 1993, 1994; Smith et al., 1997). The fact that NT produces dose-dependent antinociceptive and anti-analgesic effects by acting on distinct classes of RVM neurons (ON-cells and OFF-cells) expressing different NT receptor types (NTS1 and NTS2) may explain these contrasting results (Urban and Gebhart, 1997; Urban et al., 1999; Neubert et al., 2004).
Descending control of nociception: Specificity, recruitment and plasticity
2009, Brain Research ReviewsCitation Excerpt :Focal application of opioids in the RVM evokes analgesia, whereas the neuropeptide cholecystokinin produces behavioral hyperalgesia (Heinricher and Morgan, 1999; Heinricher and Neubert, 2004; Kovelowski et al., 2000). Whether neurotensin microinjection in the RVM produces analgesia or hyperalgesia varies with dose, and presumably, the receptor type activated (Buhler et al, 2005; Neubert et al., 2004; Smith et al., 1997; Urban and Smith, 1994). The effects of RVM inactivation are similarly complex.
Neurotensin and pain modulation
2006, Peptides