Free d-serine, d-aspartate and d-alanine in central nervous system and serum in mutant mice lacking d-amino acid oxidase

doi:10.1016/0304-3940(93)90476-2

Neuroscience Letters

Volume 152, Issues 1–2, 2 April 1993, Pages 33-36

https://doi.org/10.1016/0304-3940(93)90476-2 Get rights and content

Abstract

We have examined whether d-amino acid oxidase (DAO) regulates free d-serine content using mutant ddY/DAO⁻ mice lacking DAO activity. We find that the content of d-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral d-serine level is observed between the two strains. These results suggest that, although DAO may participate in the catabolism of d-serine in the cerebellum and periphery, there appears to be other mechanisms for catabolism of endogenous d-serine in the brain.

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¹: A. Hashimoto is a Visiting Scientist of National Institute of Neuroscience from Group of Cell and Information, Precursory Research for Embryonic Science and Technology, Research Development Corporation of Japan, 2-5-2, Nagata-cho, Chiyoda-ku, Tokyo 100, Japan.

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Free d-serine, d-aspartate and d-alanine in central nervous system and serum in mutant mice lacking d-amino acid oxidase

Abstract

Eur. J. Pharmacol.

Pharmacol. Biochem. Behav.

Life Sci.

Biochem. Biophys. Res. Commun.

FEBS Lett.

J. Chromatogr.

J. Biol. Chem.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Life Sci.

Biochem. Biophys. Res. Commun.

d-Amino acids in animals

Science