Evidence for D1 dopamine receptor-mediated modulation of the synaptic transmission from motor axon collaterals to Renshaw cells in the rat spinal cord
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Cited by (13)
Caffeine stimulates locomotor activity in the mammalian spinal cord via adenosine A<inf>1</inf> receptor-dopamine D<inf>1</inf> receptor interaction and PKA-dependent mechanisms
2016, NeuropharmacologyCitation Excerpt :Dopamine is not produced locally in the spinal cord being supplied by supraspinal centers such as the diencephalon where DA receptors and fibers projecting from the A11 region are present in the ventral horn of the adult spinal cord (Bjorklund and Skagerberg, 1979; Weil-Fugazza and Godefroy, 1993; Yoshida and Tanaka, 1988; Holstege et al., 1996; Qu et al., 2006). Thus, we can assess the modulatory effects of caffeine in the absence of dopamine since it has been shown that dopamine acts mainly as an excitatory modulator of spinal locomotor circuits working mainly through D1 receptors (Maitra et al., 1993; Seth et al., 1993; Barrière et al., 2004; Madriaga et al., 2004; Han et al., 2007). We proceeded to elicit locomotor activity using 5-HT and NMDA only, which has been shown to elicit locomotor activity reliably in rodents (see Kiehn, 2006), and then added caffeine (50 μM) to the superfusate.
Modulation of AMPA currents by D<inf>1</inf>-like but not D<inf>2</inf>-like receptors in spinal motoneurons
2009, NeuroscienceCitation Excerpt :Our data suggest that over short periods, activation of D1-like receptors increases the open probability and open duration of AMPA channels. Our data provide one mechanism whereby activation of D1 receptors can increase the excitability of spinal motor networks in rats (Seth et al., 1993; Barriere et al., 2004) and mice (Madriaga et al., 2004). In combination with our previous work demonstrating that DA enhances motoneuronal sEPSCs and mEPSCs and enhances puff-evoked AMPA currents (Han et al., 2007), our work strongly suggests that DA's modulation of AMPA channels through D1-like receptors is an important mechanism contributing to motoneuron excitability.
Developmental stage-dependent switching in the neuromodulation of vertebrate locomotor central pattern generator networks
2020, Developmental NeurobiologyOptogenetic Activation of A11 Region Increases Motor Activity
2018, Frontiers in Neural CircuitsGliotransmission and adenosinergic modulation: Insights from mammalian spinal motor networks
2017, Journal of Neurophysiology
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Present address: Physiologisches Institut, Heinrich-Heine-Universität, Düsseldorf, FRG.