Elsevier

Neuroscience Letters

Volume 122, Issue 1, 14 January 1991, Pages 50-52
Neuroscience Letters

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus

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Abstract

The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late IPSPs evoked by direct activation of interneurons in the presence of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and d,l-2-amino-5-phosphonovalerate (APV). Directly activated IPSPs were unchanged by the selective adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT), but CPT reversed hyperpolarization and depression of late IPSPs produced by adenosine. These results indicate that adenosine depresses disynaptic IPSPs in area CA1 by decreasing synaptic activation of inhibitory neurons.

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    Indeed, removal of adenosine tone ameliorated any EPSC enhancement by CBZ and OXC, confirming a tonic baseline presynaptic inhibition of glutamate release. Adenosine is known to be present in nervous tissue at high levels, leading to tonic inhibition of synaptic transmission through the activation of A1ARs (Etherington and Frenguelli, 2004; Lambert and Teyler, 1991; Wu and Saggau, 1994). A1ARs show high expression in hippocampal principal cells (Goodman and Synder, 1982), but not in interneurons (Dunwiddie and Fredholm, 1989; Lambert and Teyler, 1991), with adenosine application directly inhibiting glutamate, but not GABA release (Lambert and Teyler, 1991).

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