Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus
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2020, Pharmacological ResearchCarbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist action at adenosine A1 receptors
2015, NeuropharmacologyCitation Excerpt :Indeed, removal of adenosine tone ameliorated any EPSC enhancement by CBZ and OXC, confirming a tonic baseline presynaptic inhibition of glutamate release. Adenosine is known to be present in nervous tissue at high levels, leading to tonic inhibition of synaptic transmission through the activation of A1ARs (Etherington and Frenguelli, 2004; Lambert and Teyler, 1991; Wu and Saggau, 1994). A1ARs show high expression in hippocampal principal cells (Goodman and Synder, 1982), but not in interneurons (Dunwiddie and Fredholm, 1989; Lambert and Teyler, 1991), with adenosine application directly inhibiting glutamate, but not GABA release (Lambert and Teyler, 1991).
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