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D2 Receptors in the Periaqueductal Gray/Dorsal Raphe Modulate Peripheral Inflammatory Hyperalgesia via the Rostral Ventral Medulla
2021, NeuroscienceCitation Excerpt :Since then, several studies have demonstrated that the PAG and RVM are primary sites of analgesic action by opioids (Pert and Yaksh, 1975; Manning et al., 1994; Lane et al., 2005) and cannabinoids (Hohmann et al., 2005). It was long thought that antinociceptive actions of this pathway were mediated by opioid inhibition of GABAergic interneurons in the PAG (Vaughan and Christie, 1997; Vaughan et al., 1997) leading to activation of glutamatergic projections to the RVM (Wiklund et al., 1988; Beitz, 1990; Reichling and Basbaum, 1990). In turn, activation of RVM neurons with terminal projections in the dorsal horn of the spinal cord would result in inhibition of ascending nociceptive signals.
Descending modulation of pain: The GABA disinhibition hypothesis of analgesia
2014, Current Opinion in NeurobiologyCitation Excerpt :The predominant ‘lateral inhibition’ model assumes disinhibition of an excitatory glutamatergic projection from the PAG to the RVM [2•] (Figure 1b). The involvement of an excitatory projection was partly deduced based on early anatomical evidence suggesting that PAG–RVM projection neurons are glutamatergic [36,37]. Indeed, a recent study has shown that retrogradely labelled PAG–RVM projection neurons form a distinct population from inhibitory GABAergic neurons identified using GAD67-GFP transgenic mice [29••].
Midazolam attenuates the antinociception induced by d-serine or morphine at the supraspinal level in rats
2008, European Journal of PharmacologyPro-nociceptive action of cholecystokinin in the periaqueductal grey: A role in neuropathic and anxiety-induced hyperalgesic states
2008, Neuroscience and Biobehavioral Reviews