Selective neuronal vulnerability to hypoxia in vitro
References (13)
Kainic acid and penicillin: differential effects on excitatory and inhibitory interactions in the CA1 region of the hippocampal slice
Brain Res.
(1985)- et al.
Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the rat
Brain Res.
(1984) - et al.
Selective degeneration of interneurons in the motor cortex of infant monkeys following controlled hypoxia: a possible cause of epilepsy
Brain Res.
(1980) - et al.
Unit analysis of hippocampal population spikes
Exp. Brain Res.
(1971) - et al.
Hypoxia and vascular disorders of the central nervous system
- et al.
Selective necrosis and total necrosis in focal cerebral ischemia
Neuropathologic observations on experimental middle cerebral artery occlusion in the macaque monkey
J. Neuropathol. Exp. Neurol.
(1984)
Cited by (54)
TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner
2021, Brain, Behavior, and ImmunityCitation Excerpt :Here, we report that TLR2- and TLR3-activated microglia induce different levels of neuronal network dysfunction in a context-dependent manner, with virtually no neurodegeneration. The variability in some of our data sets might reflect differences in start of exposures, properties of microglia and/or sensitivities of neuronal networks in the ventral and the dorsal hippocampus, from both of which slices were included in our study (Aitken and Schiff, 1986; Bragdon et al., 1986; Jinno et al., 2007). Central and peripheral injections of TLR ligands have been related to alterations in brain function and integrity (Carpentier et al., 2008; Hanke and Kielian, 2011).
Preconditioning hippocampal slices with hypothermia promotes rapid tolerance to hypoxic depolarization and swelling: Mediation by erythropoietin
2020, Brain ResearchCitation Excerpt :We have shown previously that hippocampal slices preincubated for 1–2 hrs at room temperature prior to warming to near-body temperature, one of two common protocols for preparing brain slices (Davis et al., 1986; Lipton et al., 1995), show differential vulnerability to acute hypoxic injury, as indicated by regional differences in depolarization and swelling in response to severe hypoxia (Kreisman et al., 2000). Such regional differences to acute hypoxic injury are well documented in hippocampal slices (Aitken and Schiff, 1986; Balestrino et al., 1989; Somjen et al., 1990; Somjen, 2001) and a similar pattern of selective vulnerability to hypoxic/ischemic injury is observed in the hippocampi of animals and humans in vivo (Schmidt-Kastner and Freund, 1991). Additionally, preincubation of hippocampal slices under hypothermic conditions, before warming to near-normal body temperature, protects CA3 neurons from hypoxic depolarization (Davis et al., 1986).
Acute hypoxic gas breathing severely impairs cognition and task learning in humans
2015, Physiology and BehaviorSelective vulnerability of hippocampal sub-fields to oxygen-glucose deprivation is a function of animal age
2014, Brain ResearchCitation Excerpt :The microcirculation of the CA1 region is such that the area is supplied with less blood than other regions of the forebrain, and that there is less blood flow to the area upon reperfusion (Imdahl and Hossmann, 1986); taken together, both of these features provide support for Spielmeyer's assertion that regional susceptibility within the hippocampus is attributable to vascular factors. However, a number of studies (Aitken and Schiff, 1986; Kass and Lipton, 1986; Cherubini et al., 1989), along with the present report, have indicated that innate differences among hippocampal cell populations may also contribute to regional variability. In addition to providing further evidence for the notion of pathoclisis, our study also shows that the differences may not be stable across the lifespan; notably, a loss of regional variability within the hippocampus may be an additional feature associated with brain aging.
Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A<inf>2A</inf> adenosine receptors
2013, NeuropharmacologyCitation Excerpt :Application of 7-min OGD in DG induces AD and the block of synaptic activity only in 45% of the slices examined. In the DG, in order to constantly induce the appearance of AD and synaptic block, it is necessary to prolong OGD duration to 9 min, in agreement with previous observations (Aitken and Schiff, 1986; Balestrino et al., 1989; Kass and Lipton, 1986). The CA1 susceptibility to prolonged and severe AD depolarization may emphasize the selective vulnerability of CA1 neurons to hypoxic and ischemic damage.
Quercetin in Hypoxia-Induced Oxidative Stress: Novel Target for Neuroprotection
2012, International Review of NeurobiologyCitation Excerpt :It is well documented that quercetin have anti-inflammatory and antioxidant properties and it is being investigated for a wide range of potential health benefits. Primary hippocampal culture is reported as very useful tool in elucidating the cellular and molecular mechanisms involved in various diseases, because these neurons are selectively vulnerable to the effect of hypoxia and ischemia both in vivo (Balestrino and Aitken-Somjen, 1989) and in vitro (Aitken and Schiff, 1986). However, the biochemical events that responsible the degeneration of hippocampal neurons during hypoxia remains poorly understood.