Effects of estrogens on the responses of caudate neurons to microiontophoretically applied dopamine

doi:10.1016/0304-3940(81)90225-1

Neuroscience Letters

Volume 21, Issue 3, 6 February 1981, Pages 325-331

https://doi.org/10.1016/0304-3940(81)90225-1 Get rights and content

Abstract

The electrical activity of caudate neurons and their response to iontophoretically applied dopamine (DA) were tested at different time intervals before and after an i.m. injection of estradiol benzoate in rats ovariectomized one week previously. One hundred and three neurons were recorded before estradiol injection and, of these, 25% were spontaneously active and 75% were driven by glutamate. The firing activity of the majority (86%) of the neurons was inhibited on application of DA. At 2–6 after the estradiol injections, the proportion of spontaneously active neurons was elevated to 87% and their firing rate was dramatically increased. Concomitantly, the proportion of cells affected by DA decreased to 39%; moreover, the majority of cells responsive to DA was now excited following it. We conclude that estrogens are able to influence the global activity of caudate neurons and to reverse their sensitivity to DA. This action may be partly mediated by the pituitary since it was not observed in ovariectomized rats which were also hypophysectomized.

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Effects of estrogens on the responses of caudate neurons to microiontophoretically applied dopamine

Abstract

Lancet

Europ. J. Pharmacol.

Molec. cell. Endocr.

Brain Res.

Brain Res.

J. biol. Chem.

Effects of estrogens on apomorphine-induced circling behavior in the rat

Canad. J. Physiol.

Metabolism and protein binding of sex steroids in target organs: an approach to mechanism of hormone action

Rec. Progr. Horm. Res.

Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis

J. Pharmacol. exp. Ther.

Effects of estrogen and progesterone on serum and pituitary prolactin levels in ovariectomized rats

Endocrinology

Caudate nucleus neurons: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine

J. Physiol. (Lond.)

Modulation of pituitary thyrotropin releasing hormone receptor levels by estrogens and thyroid hormones

Endocrinology

Changes in pituitary thyrotropin-releasing hormone receptor level and prolactin response to TRH during the rat estrous cycle

Endocrinology

Membrane effects of thyrotropin-releasing hormone and estrogen shown by intracellular recording from pituitary cells

Science

Dopamine inhibition of action potentials in a prolactin cell line is modulated by estrogen

Nature (Lond.)

Effect of estrogen on changes in the activity of striatal cholinergic neurons induced by DA drugs

Brain Res.