The role of mesencephalic and thalamic arousal systems in experimental seizures
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Vagus nerve stimulation
2023, Neurostimulation for Epilepsy: Advances, Applications and OpportunitiesModeling early-onset post-ischemic seizures in aging mice
2015, Experimental NeurologyCitation Excerpt :Furthermore, generalized tonic–clonic seizures in patients with temporal lobe epilepsy do not always have corresponding cortical EEG discharges (Schindler et al., 2007) but tend to correlate with abnormally increased cerebral blood flow in deeper brain structures, including the brainstem (Blumenfeld et al., 2009). The role of subcortical structures in seizure generation and propagation has long been recognized in animal models (Gale, 1992; Miller, 1992). In particular, CS with rapid running, jumping, and/or barrel-rolling have been observed in rodent models of brainstem electrical kindling (Omori et al., 2001; Lam et al., 2010) and audiogenic seizures during ethanol withdrawal (Yang et al., 2003).
Effect of repeated administration of Annona diversifolia Saff. (ilama) extracts and palmitone on rat amygdala kindling
2009, Epilepsy and BehaviorCitation Excerpt :Focal epileptiform discharges originating from discrete areas of the brain have been well studied in experimental models in which chemicals have been locally introduced into specific cerebral areas [19,20], but a more limited number of experimental models address the origin of bilaterally synchronous and generalized spike–wave discharges as do kindling models [21]. In this respect, differences in behavioral and EEG manifestations of seizure stages in electrical kindling have been associated with activation of different structures such as thalamus, brainstem, and motor cortex [21–23]. In the near future we expect to further our experiments by stimulating structures other than the amygdala and to test these models in the presence of extracts of A. diversifolia Saff.
The laterodorsal tegmentum and seizure regulation: Revisiting the evidence
2023, Journal of Neuroscience Research