Evoked potentials recorded from the auditory cortex in man: evaluation and topography of the middle latency components

doi:10.1016/0168-5597(94)90064-7

Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section

Volume 92, Issue 3, May 1994, Pages 204-214

https://doi.org/10.1016/0168-5597(94)90064-7 Get rights and content

Abstract

The goal of this study is to determine and localize the generators of different components of middle latency auditory evoked potentials (MLAEPs) through intracerebral recording in auditory cortex in man (Heschl's gyrus and planum temporale).

The present results show that the generators of components at 30, 50, 60 and 75 msec latency are distributed medio-laterally along Heschl's gyrus. The 30 msec component is generated in the dorso-postero-medial part of Heschl's gyrus (primary area) and the 50 msec component is generated laterally in the primary area. The generators of the later components (60–75 msec) are localized in the lateral part of Heschl's gyrus that forms the secondary areas.

The localization of N100 generators is discussed.

References (54)

J. Arezzo et al.
The sources and intracerebral distribution of auditory evoked potentials in the alert rhesus monkey
Brain Res.
(1975)
G.E. Chatrian et al.
Response to clicks from the human brain: some depth electrographic observations
Electroenceph. clin. Neurophysiol.
(1960)
M.M. Cohen
Coronal topography of the middle latency auditory evoked potentials (MLAEPs) in man
Electroenceph. clin. Neurophysiol.
(1982)
M.P. Deiber et al.
Sequential mapping favours the hypothesis of distinct generators for Na and Pa middle latency auditory evoked potentials
Electroenceph. clin. Neurophysiol.
(1988)
G.D. Goff et al.
The scalp topography of human somatosensory and auditory evoked potentials
Electroenceph. clin. Neurophysiol.
(1977)
I. Hashimoto
Auditory evoked potentials from the human midbrain: slow brain stem responses
Electroenceph. clin. Neurophysiol.
(1982)
K. Kaga et al.
Evidence for a primary cortical origin of middle latency auditory evoked potentials in cats
Electroenceph. clin. Neurophysiol.
(1980)
P. Kileny et al.
Effects of cortical lesions on middle latency auditory evoked responses (MLR)
Electroenceph. clin. Neurophysiol.
(1987)
N. Kraus et al.
Auditory middle latency responses (MLRs) in patients with cortical lesions
Electroenceph. clin. Neurophysiol.
(1982)
J.P. Mäkelä et al.
Evidence for cortical origin of the 40 Hz auditory evoked response in man
Electroenceph. clin. Neurophysiol.
(1987)

Ö. Özdamar et al.

Auditory brain stem and middle latency responses in a patient with cortical deafness

Electroenceph. clin. Neurophysiol.

(1982)

F. Péronnet et al.

Coronal topography of human auditory evoked responses

Electroenceph. clin. Neurophysiol.

(1974)

T.W. Picton et al.

Human auditory evoked potentials. I. Evaluation of components

Electroenceph. clin. Neurophysiol.

(1974)

M. Reite et al.

Source location of a 50 msec latency auditory evoked field component

Electroenceph. clin. Neurophysiol.

(1988)

M. Scherg et al.

Evoked dipole source potentials of the human auditory cortex

Electroenceph. clin. Neurophysiol.

(1986)

H.L. Seldon

Structure of human auditory cortex. I. Cytoarchitectonics and dendritic distribution

Brain Res.

(1981)

H.L. Seldon

Structure of human auditory cortex. II. Axon distributions and morphological correlates of speech perception

Brain Res.

(1981)

C.W. Sem-Jacobsen et al.

Electroencephalographic rhythms from the depths of the parietal, occipital and temporal lobes in man

Electroenceph. clin. Neurophysiol.

(1956)

M. Steinschneider et al.

Speech-evoked activity in the auditory radiations and cortex of the awake monkey

Brain Res.

(1982)

M. Steinschneider et al.

Cellular generators of the cortical auditory evoked potential initial component

Electroenceph. clin. Neurophysiol.

(1992)

C.C. Wood et al.

Scalp distribution of human auditory evoked potentials. II. Evidence for overlapping sources and involvement of auditory cortex

Electroenceph. clin. Neurophysiol.

(1982)

D.L. Woods et al.

Generators of middle and long latency auditory evoked potentials: implications from studies of patients with bitemporal lesions

Electroenceph. clin. Neurophysiol.

(1987)

J. Bancaud et al.

Clinical semiology of frontal lobe seizures

J. Bancaud et al.

La Stéréoélectroencéphalographie dans l'Epilepsie: Informations Neurophysiopathologiques Apportées par l'Investigation Fonctionnelle Stéréotaxique

(1965)

J. Bancaud et al.

EEG et SEEG dans les Tumeurs Cérébrales et dans l'Epilepsie

(1973)

E. Başar et al.

The associations between 40 Hz EEG and the middle latency response of the auditory evoked potential

Int. J. Neurosci.

(1987)

K. Brodman

Vergleichende Lokalisationslehre der Grosshirnrinde

Cited by (548)

Exploring the Differences Between an Immature and a Mature Human Auditory System Through Auditory Late Responses in Quiet and in Noise
2024, Neuroscience
Children are disadvantaged compared to adults when they perceive speech in a noisy environment. Noise reduces their ability to extract and understand auditory information. Auditory-Evoked Late Responses (ALRs) offer insight into how the auditory system can process information in noise. This study investigated how noise, signal-to-noise ratio (SNR), and stimulus type affect ALRs in children and adults. Fifteen participants from each group with normal hearing were studied under various conditions. The findings revealed that both groups experienced delayed latencies and reduced amplitudes in noise but that children had fewer identifiable waves than adults. Babble noise had a significant impact on both groups, limiting the analysis to one condition: the /da/ stimulus at +10 dB SNR for the P1 wave. P1 amplitude was greater in quiet for children compared to adults, with no stimulus effect. Children generally exhibited longer latencies. N1 latency was longer in noise, with larger amplitudes in white noise compared to quiet for both groups. P2 latency was shorter with the verbal stimulus in quiet, with larger amplitudes in children than adults. N2 latency was shorter in quiet, with no amplitude differences between the groups. Overall, noise prolonged latencies and reduced amplitudes. Different noise types had varying impacts, with the eight-talker babble noise causing more disruption. Children's auditory system responded similarly to adults but may be more susceptible to noise. This research emphasizes the need to understand noise's impact on children's auditory development, given their exposure to noisy environments, requiring further exploration of noise parameters in children.
Comprehensive behavioral and physiologic assessment of peripheral and central auditory function in individuals with mild traumatic brain injury
2024, Hearing Research
Auditory complaints are frequently reported by individuals with mild traumatic brain injury (mTBI) yet remain difficult to detect in the absence of clinically significant hearing loss. This highlights a growing need to identify sensitive indices of auditory-related mTBI pathophysiology beyond pure-tone thresholds for improved hearing healthcare diagnosis and treatment. Given the heterogeneity of mTBI etiology and the diverse peripheral and central processes required for normal auditory function, the present study sought to determine the audiologic assessments sensitive to mTBI pathophysiology at the group level using a well-rounded test battery of both peripheral and central auditory system function. This test battery included pure-tone detection thresholds, word understanding in quiet, sentence understanding in noise, distortion product otoacoustic emissions (DPOAEs), middle-ear muscle reflexes (MEMRs), and auditory evoked potentials (AEPs), including auditory brainstem responses (ABRs), middle latency responses (MLRs), and late latency responses (LLRs). Each participant also received magnetic resonance imaging (MRI). Compared to the control group, we found that individuals with mTBI had reduced DPOAE amplitudes that revealed a compound effect of age, elevated MEMR thresholds for an ipsilateral broadband noise elicitor, longer ABR Wave I latencies for click and 4 kHz tone burst elicitors, longer ABR Wave III latencies for 4 kHz tone bursts, larger MLR Na and Nb amplitudes, smaller MLR Pb amplitudes, longer MLR Pa latencies, and smaller LLR N1 amplitudes for older individuals with mTBI. Further, mTBI individuals with combined hearing difficulty and noise sensitivity had a greater number of deficits on thalamic and cortical AEP measures compared to those with only one/no self-reported auditory symptoms. This finding was corroborated with MRI, which revealed significant structural differences in the auditory cortical areas of mTBI participants who reported combined hearing difficulty and noise sensitivity, including an enlargement of left transverse temporal gyrus (TTG) and bilateral planum polare (PP). These findings highlight the need for continued investigations toward identifying individualized audiologic assessments and treatments that are sensitive to mTBI pathophysiology.
A multidimensional characterization of the neurocognitive architecture underlying age-related temporal speech processing
2023, NeuroImage
Healthy aging is often associated with speech comprehension difficulties in everyday life situations despite a pure-tone hearing threshold in the normative range. Drawing on this background, we used a multidimensional approach to assess the functional and structural neural correlates underlying age-related temporal speech processing while controlling for pure-tone hearing acuity. Accordingly, we combined structural magnetic resonance imaging and electroencephalography, and collected behavioral data while younger and older adults completed a phonetic categorization and discrimination task with consonant-vowel syllables varying along a voice-onset time continuum. The behavioral results confirmed age-related temporal speech processing singularities which were reflected in a shift of the boundary of the psychometric categorization function, with older adults perceiving more syllable characterized by a short voice-onset time as /ta/ compared to younger adults. Furthermore, despite the absence of any between-group differences in phonetic discrimination abilities, older adults demonstrated longer N100/P200 latencies as well as increased P200 amplitudes while processing the consonant-vowel syllables varying in voice-onset time. Finally, older adults also exhibited a divergent anatomical gray matter infrastructure in bilateral auditory-related and frontal brain regions, as manifested in reduced cortical thickness and surface area. Notably, in the younger adults but not in the older adult cohort, cortical surface area in these two gross anatomical clusters correlated with the categorization of consonant-vowel syllables characterized by a short voice-onset time, suggesting the existence of a critical gray matter threshold that is crucial for consistent mapping of phonetic categories varying along the temporal dimension. Taken together, our results highlight the multifaceted dimensions of age-related temporal speech processing characteristics, and pave the way toward a better understanding of the relationships between hearing, speech and the brain in older age.
Effects of transcutaneous auricular vagus nerve stimulation paired with tones on electrophysiological markers of auditory perception
2023, Brain Stimulation
Transcutaneous auricular vagus nerve stimulation (taVNS) has been introduced as a non-invasive alternative to invasive vagus nerve stimulation (iVNS). While iVNS paired with tones has been highlighted as a potential effective therapy for the treatment of auditory disorders such as tinnitus, there is still scarce data available confirming the efficacy of non-invasive taVNS. Here, we assessed the effect of taVNS paired with acoustic stimuli on sensory-related electrophysiological responses.
A total of 22 healthy participants were investigated with a taVNS tone-pairing paradigm using a within-subjects design. In a single session pure tones paired with either active taVNS or sham taVNS were repeatedly presented. Novel tones without electrical stimulation served as control condition. Auditory event related potentials and auditory cortex oscillations were compared before and after the tone pairing procedure between stimulation conditions.
From pre to post pairing, we observed a decrease in the N1 amplitude and in theta power to tones paired with sham taVNS while these electrophysiological measures remained stable for tones paired with active taVNS a pattern mirroring auditory sensory processing of novel, unpaired control tones.
Our results demonstrate the efficacy of a short-term application of non-invasive taVNS to modulate auditory processing in healthy individuals and, thereby, have potential implications for interventions in auditory processing deficits.
Foreign speech sound discrimination and associative word learning lead to a fast reconfiguration of resting-state networks
2023, NeuroImage
Learning new words in an unfamiliar language is a complex endeavor that requires the orchestration of multiple perceptual and cognitive functions. Although the neural mechanisms governing word learning are becoming better understood, little is known about the predictive value of resting-state (RS) metrics for foreign word discrimination and word learning attainment. In addition, it is still unknown which of the multistep processes involved in word learning have the potential to rapidly reconfigure RS networks. To address these research questions, we used electroencephalography (EEG), measured forty participants, and examined scalp-based power spectra, source-based spectral density maps and functional connectivity metrics before (RS1), in between (RS2) and after (RS3) a series of tasks which are known to facilitate the acquisition of new words in a foreign language, namely word discrimination, word-referent mapping and semantic generalization. Power spectra at the scalp level consistently revealed a reconfiguration of RS networks as a function of foreign word discrimination (RS1 vs. RS2) and word learning (RS1 vs. RS3) tasks in the delta, lower and upper alpha, and upper beta frequency ranges. Otherwise, functional reconfigurations at the source level were restricted to the theta (spectral density maps) and to the lower and upper alpha frequency bands (spectral density maps and functional connectivity). Notably, scalp RS changes related to the word discrimination tasks (difference between RS2 and RS1) correlated with word discrimination abilities (upper alpha band) and semantic generalization performance (theta and upper alpha bands), whereas functional changes related to the word learning tasks (difference between RS3 and RS1) correlated with word discrimination scores (lower alpha band). Taken together, these results highlight that foreign speech sound discrimination and word learning have the potential to rapidly reconfigure RS networks at multiple functional scales.
Reconstruction and localization of auditory sources from intracerebral SEEG using independent component analysis
2023, NeuroImage
Stereo-electroencephalography (SEEG) is the surgical implantation of electrodes in the brain to better localize the epileptic network in pharmaco-resistant epileptic patients. This technique has exquisite spatial and temporal resolution. Still, the number and the position of the electrodes in the brain is limited and determined by the semiology and/or preliminary non-invasive examinations, leading to a large number of unexplored brain structures in each patient. Here, we propose a new approach to reconstruct the activity of non-sampled structures in SEEG, based on independent component analysis (ICA) and dipole source localization. We have tested this approach with an auditory stimulation dataset in ten patients. The activity directly recorded from the auditory cortex served as ground truth and was compared to the ICA applied on all non-auditory electrodes. Our results show that the activity from the auditory cortex can be reconstructed at the single trial level from contacts as far as ∼40 mm from the source. Importantly, this reconstructed activity is localized via dipole fitting in the proximity of the original source. In addition, we show that the size of the confidence interval of the dipole fitting is a good indicator of the reliability of the result, which depends on the geometry of the SEEG implantation. Overall, our approach allows reconstructing the activity of structures far from the electrode locations, partially overcoming the spatial sampling limitation of intracerebral recordings.

View all citing articles on Scopus

View full text