Trends in Neurosciences
ReviewThe determination of neuronal fate in the cerebral cortex
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NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification and manipulation of mouse neurons
2021, Cell Reports MethodsCitation Excerpt :Mounting evidence shows that neurogenic timing, which is often referred to as the neuronal birthdate, has immense impacts on neuronal phenotypes. In the neocortex, the birthdate determines layer positioning, connection patterns, and molecular and physiological properties of neurons (McConnell, 1989; Lodato and Arlotta, 2015). The chronological specification of neuronal fates is not a unique property of the neocortex but rather a generally conserved strategy in various nervous systems for generating neuronal diversity (Suzuki and Hirata, 2013).
The regulation of cortical neurogenesis
2021, Current Topics in Developmental BiologyCitation Excerpt :The basis for our mechanistic understanding of this process lies on pioneering studies by Susan McConnell using cell transplantation strategies in developing ferrets (McConnell, 1985). By taking neural progenitor cells from the cortical primordium of one embryo, labeling them and transplanting into an embryo of a different developmental stage, she demonstrated that at each age cortical progenitor cells are imprinted with an intrinsic program to heavily bias neuron production to only one layer (McConnell, 1988; McConnell, 1989; McConnell & Kaznowski, 1991). Intriguingly, progenitor cells transplanted while in S-phase of the cell cycle change the fate of their daughter neurons to that of those being born in the host embryo.
Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development
2019, Seminars in Cell and Developmental BiologyAltered GABAergic function, cortical microcircuitry, and information processing in depression
2019, Neurobiology of Depression: Road to Novel TherapeuticsDevelopment of the Nervous System
2018, Fundamental Neuroscience for Basic and Clinical Applications: Fifth EditionDevelopmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila
2013, CellCitation Excerpt :Progressive loss of competence has been well characterized in mammalian and insect neural progenitors, in which single progenitors make an ordered series of distinct neural progeny (reviewed in Cepko et al., 1996; Kwan et al., 2012; Pearson and Doe, 2004; Sousa-Nunes et al., 2010). For example, mammalian neural progenitors have an early competence window to generate neuronal subtypes and a later competence window to generate glia (reviewed in McConnell, 1989; Okano and Temple, 2009). Yet virtually nothing is known about how competence is regulated in any mammalian or insect progenitor cell lineage.